Periapical Periodontitis Clinical Trial
Official title:
Encapsulated Mesenchymal Stem Cells for Endodontic Treatment of Permanent Teeth With Apical Lesion: a Controlled Clinical Trial.
To compare the dental survival in a period of one year of mature permanent teeth with apical lesion following the administration of encapsulated Mesenchymal Stem Cells under a regenerative endodontic procedure and a conventional root canal treatment.
This is a controlled clinical trial designed to evaluate the survival of mature permanent teeth with apical lesion treated with regenerative endodontic procedure (REP) based on encapsulated Mesenchymal Stem Cells in a biological scaffold. The REP will be compared to the conventional endodontic therapy. The REP is based on the use of umbilical cord-derived mesenchymal stem cells encapsulated in a plasma-derived biomaterial . The study group will use the disinfection protocol, indicated in the clinical considerations for regenerative procedures as recommended by the American Association of Endodontics, using a paste of calcium hydroxide prepared with double-distilled water as intracanal medication, and will be operated with REP using allogeneic stem cells in a scaffold, while the control group will be operated with conventional endodontic therapy alone. This clinical trial pretends to determine the dental survival of the tooth with mature apex and apical lesion, over a period of one year. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT00226148 -
Immediate Implant Placement in the Molar Regions
|
Phase 0 | |
| Completed |
NCT05718596 -
Quantitative Assessment of the Efficacy of Sweeps Laser Activation Systems
|
N/A | |
| Recruiting |
NCT00762840 -
Safety and Efficacy of the Apexum Ablator
|
N/A | |
| Recruiting |
NCT05525013 -
Effect of Simvastatin Versus Calcium Hydroxide Intracanal Medications on Post-operative Pain and Interleukin 6 and 8
|
N/A | |
| Active, not recruiting |
NCT05555043 -
Comparison of Clinical Outcomes Between GentleWave® and Biolase®
|
N/A | |
| Recruiting |
NCT06322979 -
Premixed Bioceramic Putty as an Apical Plug in Immature Anterior Permanent Teeth
|
N/A | |
| Completed |
NCT02947763 -
Single Versus Multiple Visits Endodontic Treatment
|
Phase 1 | |
| Completed |
NCT05857436 -
Relationship Apical Periodontitis and the Main Bacterial Species in the Oral Microbiota
|
N/A | |
| Active, not recruiting |
NCT03660163 -
Assessment of the Outcome of Endodontic Treatment Using Cone Beam Computed Tomography.
|
||
| Completed |
NCT02801552 -
Regenerative Endodontic Procedure of Immature Permanent Teeth With Apical Periodontitis Using PRF
|
N/A | |
| Completed |
NCT02632513 -
Effect of Passive Ultrasonic Irrigation on Success of Primary Endodontic Treatment
|
N/A | |
| Completed |
NCT01312194 -
Periapical Healing After One or Two-visits to Endodontic Treatment in Adolescents Patients
|
N/A | |
| Completed |
NCT00223327 -
Measurement of Bite Force in Humans
|
Phase 0 | |
| Completed |
NCT05297747 -
Adrenomedullin Upregulation in Apical Periodontitis
|
N/A | |
| Completed |
NCT03708081 -
Comparative Evaluation of Different File Systems in Postoperative Pain
|
||
| Recruiting |
NCT01799187 -
Research of Revascularization in Immature Teeth With Periapical Periodontitis
|
N/A | |
| Completed |
NCT06023901 -
The Importance of Prostaglandin and Nitric Oxide Synthesis in Apical Periodontitis
|
N/A | |
| Completed |
NCT02747082 -
Antibacterial Effectiveness of Two Root Canal Irrigants
|
Phase 2 | |
| Completed |
NCT06339905 -
The Effects of EndoActivator on Postoperative Pain and Root Canal Treatment Success
|
N/A | |
| Completed |
NCT05719987 -
Biodentine as an Apical Plug in Immature Permanent Molars
|
N/A |