Single Versus Multiple Visits Endodontic Treatment

Periapical Periodontitis Clinical Trial

Official title:

Healing Rates After Single Versus Multiple Visits Endodontic Treatment of Necrotic Teeth With Apical Periodontitis: A Randomized Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02947763
• Other study ID #: CEBD-CU-2016-10-231
• Status: Completed
• Phase: Phase 1
• Start date: November 2016
• Est. completion date: February 2018

Study information

• Verified date: July 2019
• Source: Cairo University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Healing rate after single visit or multiple visit endodontic treatment using triple paste intracanal medicament will be assessed both clinically and radio-graphically for follow-up period up to one year

Description:

Patients with necrotic teeth with apical periodontitis will be selected according to the eligibility criteria and patients are then randomized to either single visit or multiple visit using triple paste intracanal medicament. Postoperative pain will then assessed using numerical rating scale after 1, 2, 3 and 7 days post-instrumentation. Radiographic healing will be assessed every 3 months up to one year.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 44
• Est. completion date: February 2018
• Est. primary completion date: January 2018
• Accepts healthy volunteers: No
• Gender: All
• Age group: 16 Years to 55 Years

Eligibility

Inclusion Criteria:

1. Adult patients; age between 16-55 years old.

2. Males or Females.

3. Maxillary or mandibular single-root tooth or a multi-rooted tooth with:

• Non-vital response of pulp tissue.

• Radiographic evidence of periapical lesions (minimum size 2.0 mm × 2.0 mm) related to one root in case of multi-rooted teeth.

• Asymptomatic patients.

4. Positive patients' acceptance for participation in the study.

Exclusion Criteria:

1. Primary teeth, and permanent teeth with immature apex.

2. Teeth previously accessed or endodontically treated.

3. Patients with diabetes and immune-compromising disease.

4. Patients allergic to metronidazole, ciprofloxacin, or minocycline.

5. Vital cases or necrotic without periapical lesion.

6. Pregnant women.

7. Teeth with unfavorable conditions for rubber-dam application.

8. Tooth associated with vertical root fracture, coronal perforation, calcification and external or internal root resorption.

Related Conditions & MeSH terms

• Periapical Periodontitis
• Periodontitis

Intervention

Drug:
• mixture of metronidazole, ciprofloxacin, and minocycline
placement of intracanal medication

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Cairo University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	postoperative pain	using numerical rating scale from 0-10	24 hours
Primary	postoperative pain	using numerical rating scale from 0-10	48 hours
Primary	postoperative pain	using numerical rating scale from 0-10	72 hours
Primary	postoperative pain	using numerical rating scale from 0-10	7 days
Secondary	Radiographic healing	using digital radiography	3 months
Secondary	Radiographic healing	using digital radiography	6 months
Secondary	Radiographic healing	using digital radiography	9 months
Secondary	Radiographic healing	using digital radiography	12 months