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Perfusion clinical trials

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NCT ID: NCT06421103 Recruiting - Perfusion Clinical Trials

Micro-dosing Indocyanine Green (ICG) in Children

Start date: June 2024
Phase: N/A
Study type: Interventional

The goal of this cohort study is to identify the lowest dose of Indocyanine Green (ICG) that achieves satisfactory intra-operative fluorescence for the assessment of gastrointestinal or genitourinary tract perfusion in children.

NCT ID: NCT06222645 Recruiting - Perfusion Clinical Trials

PPG vs. ICG in Gastrointestinal Resections

Start date: November 1, 2023
Phase: N/A
Study type: Interventional

In this study, gastrointestinal anastomoses are examined with imaging Photoplethysmography and after this the investigators use the Standard Routine ICG-Imaging. At the end, both methods will be compared.

NCT ID: NCT06220357 Completed - Perfusion Clinical Trials

Diluted Indocyanine Green Angiography: a Novel Approach to Free Flap Perfusion Evaluation in Reconstructive Microsurgery

Start date: October 10, 2022
Phase: N/A
Study type: Interventional

The evaluation of perfusion in free flaps is crucial in clinical practice. Currently, the gold standard for evaluation is subjective through clinical assessment. However, indocyanine green angiography (ICGA), a tool that uses a near-infrared (NIR) camera to depict and monitor flap vascularization, offers an objective and reproducible alternative. The population in this study were divided into three equal groups, where each groups were assessed with Indocyanine Green (Aurogreen®, Aurolab, Tamil Nadu, India). The study was conducted with three distinct concentrations of ICGA: 5 mg/mL (100% standard concentration), 2.5 mg/mL (50%), and 0.5 mg/mL (10%). Indocyanine green was given in immediate postoperative manner, after the patient defect has been reconstructed with free flap.

NCT ID: NCT06158217 Recruiting - Clinical trials for Invasive Breast Cancer

Effect of Ultrasound Combined With Microbubbles on Blood Perfusion in Invasive Breast Cancer

Start date: September 29, 2022
Phase:
Study type: Observational

Blood perfusion insufficiency and hypoxia are the main causes of drug resistance to chemotherapy in breast cancer. Increasing blood perfusion can improve drug delivery. The cavitation effect of ultrasound-stimulated microbubbles (USMBs) is known to enhance tumor blood perfusion, so we conducted a prospective human study to investigate the effects of USMBs on hemoperfusion in invasive breast cancer (IBC).

NCT ID: NCT06034834 Recruiting - Traumatic Injury Clinical Trials

Near-Infrared Imaging for Perfusion Assessment of Traumatic Soft Tissue and Skeletal Injuries

IMPACT
Start date: November 13, 2023
Phase: N/A
Study type: Interventional

To date, intraoperative assessment of tissue and bone viability is predominantly subjective, depending on the clinical view of the surgeon, resulting in a variation in the thoroughness of debridement. Inadequate initial resection leads to multiple debridement interventions, leading to prolonged hospitalization or readmission with consequently high direct medical costs. Near-Infrared Fluorescence (NIRF) imaging with Indocyanine Green (ICG) could potentially be a relevant contribution to adequately treating soft tissue and skeletal injuries by creating an improved distinction between viable and non-viable tissue, based on perfusion indices. This study evaluates whether intraoperative perfusion assessment with ICG fluorescence imaging is a feasible and quantifiable technique for treating traumatic injuries.

NCT ID: NCT05893407 Recruiting - Ischemic Stroke Clinical Trials

Brain PERfusion Evaluation by Contrast-Enhanced UltraSound

PerCEUS
Start date: July 21, 2023
Phase:
Study type: Observational

The objective of the study is to assess brain tissue perfusion by contrast-enhanced ultrasound perfusion imaging (PerCEUS) in acute brain injuries. More precisely, it aims : - to evaluate the heterogeneity of brain perfusion and thus diagnose brain tissue hypoperfusion with contrast-enhanced ultrasound. - to correlate contrast-enhanced ultrasound with perfusion measurements by usual multimodal monitoring.

NCT ID: NCT05243914 Terminated - Clinical trials for Heart Transplantation

Heart Transplantation Utilizing NRP DCD

Start date: January 21, 2022
Phase:
Study type: Observational [Patient Registry]

This is a prospective, observational, pilot trial to evaluate the feasibility of heart transplantation using normothermic regional perfusion (NRP) donation after donor circulatory death (DCD). Adults who meet standard criteria for heart transplantation listing and study-specific eligibility criteria will enroll in the study. the investigators anticipate evaluating an initial cohort of approximately 100 DCD donors for a final yield of 40 hearts. The investigators will accept donors between the ages of 18 and 65 who are determined to have heart function/quality appropriate for donation for transplantation based on available donor data and testing. If feasible, donors might be relocated to BUMCP to maintain uniformity of process, minimize cold ischemic time, and allow for more rapid and improved communication during the initial pilot phase. Recipients will be selected based on blood group, crossmatch, size match, and clinical stability per standard allocation practices. Recipients will be followed post-transplantation per BUMCP Heart Transplant standard protocol.

NCT ID: NCT04233177 Completed - Clinical trials for Perioperative/Postoperative Complications

The Effect of Trendelenburg Position on CCA Blood Flow

Start date: January 13, 2020
Phase:
Study type: Observational

The investigators will evaluate the change of the common carotid artery blood flow according to patient's position and penumoperitoneum.

NCT ID: NCT04226781 Recruiting - Perfusion Clinical Trials

ICG vs. HSI in Gastrointestinal Resections

ICGvHSI
Start date: January 2, 2020
Phase: N/A
Study type: Interventional

In this study, gastrointestinal anastomoses are examined with a hyperspectral camera and after this the investigators use the Standard Routine ICG-Imaging. At the end, both methods will be compared..

NCT ID: NCT03644420 Completed - Clinical trials for Osteoarthritis, Knee

Evaluation of Patients With Knee Osteoarthritis Receiving a Prosthesis

Chondrolike
Start date: May 2013
Phase:
Study type: Observational

Patients with osteoarthritis of the knee undergo visible joint changes in radiology and Magnetic resonance imaging (MRI) tests, but also clinically and histologically. The area of greatest change is at the subchondral/cartilage bone junction. Investigators will determine the association between preoperative clinical evaluation (IKDC and Womac scores), radiological classifications and histopathology. In addition, the role of inflammation in the pathogenesis of osteoarthritis is being given major interest, and inflammation is closely linked with vascularization. It was recently demonstrated that dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) could identify the subchondral bone marrow vascularization changes occurring in osteoarthritis in animals. These changes appeared before cartilage lesions were visible and were correlated with osteoarthritis severity. Thus the opportunity to obtain an objective assessment of bone vascularization in non-invasive conditions in humans might help better understanding osteoarthritis pathophysiology and finding new biomarkers. Investigators hypothesized that, as in animals, DCE-MRI has the ability to identify subchondral bone marrow vascularization changes in human osteoarthritis.