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Peptic Ulcer clinical trials

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NCT ID: NCT06439563 Not yet recruiting - Peptic Ulcer Clinical Trials

Study to Evaluate the Efficacy and Safety of JP-1366 in the Prevention of NSAIDs-Induced Peptic Ulcers

Start date: August 2024
Phase: Phase 3
Study type: Interventional

The sutdy aims to to demonstrate the non-inferiority of JP-1366 10 mg compared to Lanston Capsule 15 mg in preventing NSAIDs-induced peptic ulcers and to compare/evaluate the efficacy and safety of JP-1366 10 mg.

NCT ID: NCT06284876 Not yet recruiting - Peptic Ulcer Clinical Trials

Study to Evaluate the Efficacy and Safety of Ilaprazole 10 mg in Prevention NSAIDs Associated Peptic Ulcer

Start date: August 30, 2024
Phase: Phase 3
Study type: Interventional

To demonstrate the non-inferiority of Ilaprazole 10 mg to the active control in prevention of NSAIDs-associated peptic ulcer, as assessed by the proportion of subjects with peptic ulcer by Week 24

NCT ID: NCT06273384 Not yet recruiting - Clinical trials for Helicobacter Pylori Infection

Diagnostic Performance of CIM for Helicobacter Pylori Infection in Patients With Peptic Ulcer Bleeding

CIM
Start date: March 1, 2024
Phase:
Study type: Observational

The goal of this cross-sectional study is to evaluate the efficacy of current infection marker (CIM) method for H. pylori detection. The main questions it aims to answer are: - To evaluate the efficacy of CIM method for H. pylori detection compared to rapid urease test(RUT), histopathology, polymerase chain reaction (PCR), and urea breath test (UBT) in patients who presented with upper gastrointestinal hemorrhage from peptic ulcer, and their sensitivity, specificity, accuracy, positive predictive value (PPV), negative predictive value (NPV), positive likelihood ratio, and negative likelihood ratio. - To evaluate the advantages of CIM method for H. pylori detection comparing to RUT, histopathology, PCR, and UBT in patients who presented with upper gastrointestinal hemorrhage from peptic ulcer as net reclassification index (NRI). - To study the associated factors in false negative value of H. pylori detection methods with CIM, RUT, histopathology, PCR, and UBT.

NCT ID: NCT06196710 Not yet recruiting - Clinical trials for Bleeding Peptic Ulcer

The Use of OTSC in LBGDU to Standard Endoscopic Hemostatic Methods

OTSC-LBGDU
Start date: June 1, 2024
Phase: N/A
Study type: Interventional

In managing bleeding gastroduodenal ulcers, endoscopic control of bleeding is the first line treatment-further bleeding after endoscopic hemostasis is associated with a 3-fold increase in mortality. Large ulcer size (> 20 mm) predicts further bleeding. These ulcers erode into arteries of significant size (>2 mm) from either the gastro-duodenal or left gastric arterial complexes. An over-the-scope clip is an endoscopic clamp device with a high tensile strength. It can compress sizeable arteries, and firmly anchor onto the ulcer base avoiding recurrent bleeding from clip dislodgement. It therefore offers secure and durable hemostasis. In the proposed randomized controlled trial, the investigators hypothesize that after initial endoscopic control of bleeding from large gastro-duodenal ulcers (20 mm in size or more), adding an OTSC can prevent recurrent bleeding and improve patients' outcomes. Investigators enroll patients with bleeding from large ulcers as defined. After initial endoscopic control of bleeding using injection with diluted epinephrine, these patients are randomized, during endoscopy, to receive standard treatment (thermo-coagulation or hemo-clips) or an added OTSC. The primary endpoint is recurrent bleeding over 30 days confirmed on endoscopy. Secondary endpoints include the need for rescue treatment; endoscopic, angiographic embolization or surgery, red blood cell (RBC) transfusion, hospitalization, and bleeding related and all-cause mortality.

NCT ID: NCT05767320 Not yet recruiting - Clinical trials for Perforated Peptic Ulcer

Open vs Laparoscopic Repair of Perforated Peptic Ulcer

Start date: March 15, 2023
Phase: N/A
Study type: Interventional

comparison between outcomes of both open and laparoscopic repair of perforated peptic ulcer

NCT ID: NCT05715450 Not yet recruiting - Clinical trials for Perforated Peptic Ulcer

Falciformopexy for Treatment Perforated Peptic Ulcer.

Start date: May 30, 2023
Phase: N/A
Study type: Interventional

Use the falciform ligament flap for the treatment of perforated peptic ulcer

NCT ID: NCT04784910 Not yet recruiting - Peptic Ulcer Clinical Trials

Study to Evaluate the Efficacy and Safety of DWP14012 in Prevention of NSAIDs Induced Peptic Ulcer

Start date: March 2021
Phase: Phase 3
Study type: Interventional

The study aims to demonstrate the preventive effect of DWP14012 20 mg for peptic ulcer is non-inferior to that of Lansoprazole 15 mg in terms of prevention of peptic ulcer and confirm the safety of DWP14012 20 mg.

NCT ID: NCT04170270 Not yet recruiting - Clinical trials for Bleeding Peptic Ulcer

Oral Omeprazole in Bleeding Peptic Ulcer

Start date: November 2019
Phase: Early Phase 1
Study type: Interventional

Find out if there is a significant difference between clinical outcome among the patients with bleeding peptic ulcer treated with oral omeprazole compared to those treated with intravenous omeprazole.

NCT ID: NCT04123899 Not yet recruiting - Clinical trials for Gastroduodenal Ulcer

BE Study of Gaster®D Tab 20mg (Manufacturer Changed)

Start date: October 11, 2019
Phase: N/A
Study type: Interventional

An Open-Label, Randomized, Two-sequence, Two-period, Fasting Condition, Single Oral Dose, Cross-over Study of Bioequivalence of "Gaster®D Tab20mg (Famotidine) (Changed Manufacturer)" and "Gaster®D Tab 20mg (Famotidine) (Unchanged Manufacturer, Announced Reference Drug)" in Healthy, Adult, Human Subjects.

NCT ID: NCT02961296 Not yet recruiting - Lymphoma Clinical Trials

Helicobacter Pylori Antibiotic Susceptibility Testing of Korea

Start date: October 2016
Phase: N/A
Study type: Observational [Patient Registry]

The purpose of this study is to make nationwide registry for antimicrobial resistance of Helicobacter pylori using single method with agar dilution in Korea.