Penicillin Allergy Clinical Trial
Official title:
The Optimized Diagnostic Methods for the Confirmation of Beta-lactam Hypersensitivity in Thailand
The true prevalence of drug allergy in patients with a history of beta-lactam hypersensitivity will be determined by using commercially available standard skin test reagents and the diagnostic agents available in Thailand. We hypothesize that only minority of patients with such a history are truly allergic.
Patients with a history of beta-lactam hypersensitivity will be evaluated by the standard
skin test reagents (major and minor determinants of penicillin, amoxicillin, and clavulanic
if applicable), and intravenous forms of beta-lactam antibiotics .
Diagnostic values of the measurement of specific Immunoglobulin E to
penicillin/aminopenicillin and skin test reagents currently available in Thailand will be
comparatively analyzed with the standard skin test reagents.
The measurement of drug-induced interferon-gamma releasing cells will be measured in patients
with a history of non-immediate reaction.
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