Sweet Taste Responsiveness in Relation to Insulin, Leptin and Adiposity Among Obese Treatment Seeking Children

Pediatric Obesity Clinical Trial

Official title:

Sweet Taste Responsiveness in Relation to Insulin, Leptin and Adiposity Among Obese Treatment Seeking Children

Clinical Trial Details — Status: Withdrawn

Administrative data

• NCT number: NCT04600648
• Other study ID #: 00002306
• Status: Withdrawn
• Phase: N/A
• Start date: September 20, 2018
• Est. completion date: August 2, 2019

Study information

• Verified date: October 2020
• Source: State University of New York at Buffalo
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study will explore whether a relationship exists between insulin and leptin resistance, sweet taste responsiveness, and adiposity.

Description:

Compared to healthy weight peers, some reports have shown that they are less sensitive to, or perceptive of, sucrose solutions and sweet foods, whereas others have observed the opposite pattern of findings or no difference at all. Among those seeking weight loss treatment, one investigation found perception and preferences for sweet taste remained unchanged after weight loss, and another observed a decreased ability to distinguish sweet taste from other taste solutions. Given these discrepancies in the literature, the proposed study will explore whether a relationship exists between insulin and leptin resistance, sweet taste responsiveness, and adiposity.

Recruitment information / eligibility

• Status: Withdrawn
• Enrollment: 0
• Est. completion date: August 2, 2019
• Est. primary completion date: August 2, 2019
• Accepts healthy volunteers: No
• Gender: All
• Age group: 8 Years to 14 Years

Eligibility

Inclusion Criteria:

• Patient of Children's Healthy Weigh of Buffalo
• ages of 8-14

If enrolled in the bariatric arm:

• must be scheduled for bariatric surgery prior to enrollment

Exclusion Criteria:

• Patients unable to get labs drawn at a Kaleida facility
• Severe hay fever or seasonal allergies within 2 weeks of enrollment
• smoker or are exposed to second-hand smoke at home,
• has been dieting to lose weight within the past 6 months of enrollment
• currently taking any prescription medications that can influence taste or small functions or are pregnant.
• pregnancy
• Bariatric arm patients will be excluded if they fail to have the surgery.

Related Conditions & MeSH terms

• Pediatric Obesity

Intervention

Diagnostic Test:
• Serum insulin level
Measure levels before and after weight loss related to bariatric surgery
• Serum Leptin test
Measure levels before and after weight loss related to lifestyle change weight loss

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
State University of New York at Buffalo

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Higher insulin and leptin levels will be associated with lower sweet taste sensitivity and perception, and higher body fat percentage and z-BMI	insulin and leptin levels will be measured at various time points in an attempt to identify if there is a change is taste senses associated with specific variables be associated with lower sweet taste	to be measured at 6 months