Pediatric Disorder Clinical Trial
Official title:
Effect of Remimazolam and Sevoflurane Anesthesia on Recovery in Pediatric Patients Who Underwent Ophthalmic Surgery Under General Anesthesia
The most commonly used anesthetic for general anesthesia in pediatric patients is sevoflurane, an inhalation anesthetic. However, the incidence of emergence agitation after sevoflurane anesthesia in pediatric patients is high, with reports of up to 67%. Remimazolam (Byfavo Inj., Hana Pharm Col, Ltd., Seoul, Korea) has a short context-sensitive half-life of 7.5 minutes, and the time it takes from the end of anesthesia until the patient wakes up is predictable. According to a study by Yang X et al., administering a small amount of remimazolam (0.2 mg/kg) intravenously at the end of general anesthesia using sevoflurane reduced the incidence of emergence agitation. However, very few studies have evaluated the use of remimazolam in general anesthesia in pediatric patients.
- The most commonly used anesthetic for general anesthesia in pediatric patients is sevoflurane, an inhalation anesthetic. It has the advantage of being able to induce anesthesia without securing an intravenous route and causing less irritation to the airway. However, the incidence of emergence agitation after sevoflurane anesthesia in pediatric patients is high, with reports of up to 67%. Emergence agitation can cause physical damage to the patient, workload in the recovery room, and dissatisfaction of the caregiver. - Remimazolam (Byfavo Inj., Hana Pharm Col, Ltd., Seoul, Korea) is a benzodiazepine drug used for inducing and maintaining general anesthesia and for sedation during procedures. When remimazolam is used as a general anesthetic, it has the advantage of being metabolized quickly by enzymes in the liver compared to propofol, has a short context-sensitive half-life of 7.5 minutes, and can be reversed with flumazenil. Therefore, during general anesthesia using remimazolam, the time it takes from the end of anesthesia until the patient wakes up is predictable. According to a study by Yang X et al., administering a small amount of remimazolam (0.2 mg/kg) intravenously at the end of general anesthesia using sevoflurane reduced the incidence of emergence agitation. - However, very few studies have evaluated the use of remimazolam in general anesthesia in pediatric patients and its effect on endotracheal extubation time after anesthesia in operating room, emergence agitation, pain, and discharge time in the postanesthesia care unit (PACU). ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05590884 -
Gadopiclenol Pharmacokinetics, Safety and Efficacy in Children < 2 Years of Age
|
Phase 2 | |
| Completed |
NCT02261857 -
3D-Printed CPAP Masks for Children With Obstructive Sleep Apnea
|
Early Phase 1 | |
| Terminated |
NCT03305562 -
Pediatric Hypertension Registry (PHREG)
|
||
| Completed |
NCT04506203 -
The Accuracy of Pediatric Air Test as a Non-invasive Atelectasis Diagnostic Tool
|
N/A | |
| Completed |
NCT05095012 -
RECOVER Clinical Pathway for Pediatric Concussion
|
N/A | |
| Enrolling by invitation |
NCT05539456 -
Reliability and Validity of the Turkish Version of the PedsQL 3.0 Neuromuscular Module for 2-to 4- Year-old
|
||
| Enrolling by invitation |
NCT04644783 -
Novel Blood Test to Predict Safe Foods for Infants and Toddlers With Food Protein-induced Enterocolitis Syndrome (FPIES)
|
N/A | |
| Recruiting |
NCT02164773 -
Addition of Magnesium Sulfate to Caudal to Prevent Postoperative Emergence Agitation.
|
Phase 4 | |
| Completed |
NCT03977948 -
Qualitative and Systemic Assessment of a Nurse Intervention an Inpatient Child and His or Her Parents
|
||
| Completed |
NCT03358446 -
The Optimal Leg Angulation of Femoral Central Catheterization in Pediatrics
|
||
| Active, not recruiting |
NCT05087537 -
Effect of Concomitant Bladder Neck Incision and Urethral Valve Ablation on Surgical Re-intervention Rate for Patients With Posterior Urethral Valve
|
N/A | |
| Active, not recruiting |
NCT04522778 -
Innovative Central Line Securement Device in the Pediatric Population
|
N/A | |
| Completed |
NCT03966625 -
Serological Identification of Celiac Disease in Kids
|
||
| Completed |
NCT02625662 -
Facioscapulohumeral Dystrophy in Children
|
||
| Completed |
NCT03650049 -
Food Protein-induced Enterocolitis Syndrome (FPIES) in 14 Children
|
||
| Enrolling by invitation |
NCT04435821 -
PET/MRI in the Diagnosis of Pediatric Chronic Pain
|
Phase 1 | |
| Recruiting |
NCT04643015 -
New Ways of Doing Magnetic Resonance Imaging in Children and Adults
|
||
| Completed |
NCT05313295 -
Physical Therapy Treatment on Children and Adolescents With Neurological Pathologies
|
N/A | |
| Completed |
NCT03662113 -
Effect of Domperidone on Completion Rate of Vedio Capsule Endoscopy
|
N/A | |
| Not yet recruiting |
NCT05852535 -
Spontaneous Evisceration of Infantile Umbilical Hernia
|