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Clinical Trial Summary

The investigators hypothesized that in terms of granulocyte colony-stimulating factor (G-CSF) administration, the route of continuous infusion would lead to a faster neutrophil recovery compared to that of bolus administration


Clinical Trial Description

The investigators aimed to enroll 40 hospitalized patients in this phase 4 clinical trial. Patients with an ANC lower than 500 cells/mm3 will be randomly categorized into experimental and controlled arms. The experimental arm was designed to receive G-CSF intravenous infusion for 5 hours at a dose of 5 mcg/kg. The controlled arm was designed to receive a G-CSF bolus injection within one minute at a dose of 5 mcg/kg. Three days after treatment initiation, serum white blood cell and differential counts will be followed daily to determine the timing of steady neutrophil recovery. In the following time of another neutropenia event, the experimental arm would cross-switch to the controlled arm and receive corresponding G-CSF according to the study design ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06145321
Study type Interventional
Source Chang Gung Memorial Hospital
Contact Yi-Lun Wang, Bachelor
Phone 0978989072
Email mp2601@cgmh.org.tw
Status Recruiting
Phase Phase 4
Start date November 23, 2023
Completion date November 15, 2024

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