Continuous Versus Bolus Administration of G-CSF in Children With Cancer

Status Recruiting

Clinical Trial Summary

The investigators hypothesized that in terms of granulocyte colony-stimulating factor (G-CSF) administration, the route of continuous infusion would lead to a faster neutrophil recovery compared to that of bolus administration

Clinical Trial Description

The investigators aimed to enroll 40 hospitalized patients in this phase 4 clinical trial. Patients with an ANC lower than 500 cells/mm3 will be randomly categorized into experimental and controlled arms. The experimental arm was designed to receive G-CSF intravenous infusion for 5 hours at a dose of 5 mcg/kg. The controlled arm was designed to receive a G-CSF bolus injection within one minute at a dose of 5 mcg/kg. Three days after treatment initiation, serum white blood cell and differential counts will be followed daily to determine the timing of steady neutrophil recovery. In the following time of another neutropenia event, the experimental arm would cross-switch to the controlled arm and receive corresponding G-CSF according to the study design ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06145321
Study type	Interventional
Source	Chang Gung Memorial Hospital
Contact	Yi-Lun Wang, Bachelor
Phone	0978989072
Email	mp2601@cgmh.org.tw
Status	Recruiting
Phase	Phase 4
Start date	November 23, 2023
Completion date	November 15, 2024

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