CHildren Treated With Vincristine: A Trial Regarding Pharmacokinetics, DNA

Status Recruiting

Clinical Trial Summary

The goal of this clinical trial is to individualize the dosage of vincristine, a chemotherapy drug, in children with cancer. The main question it aims to answer is: can vincristine dosage be optimized while carefully monitoring toxicity. The following will happen: - Participants will receive vincristine according to the institutional treatment protocol. - After receiving vincristine, blood samples will be taken at three time points. - The amount of vincristine in the blood samples will be determined. - If the amount of vincristine in the blood samples is lower than the reference and the participants do not experience toxicity due to vincristine, the dose of vincristine may be increased. - Toxicity will be carefully monitored.

Clinical Trial Description

Vincristine is among the most widely used and potentially effective chemotherapeutic agents in pediatric oncology patients. However, in black African children it may be sub optimally dosed due to genetic differences in the metabolism of vincristine. This study aims to optimize the dosing regimen of vincristine while carefully monitoring toxicity. This will be a prospective cohort study consisting of two parts: a feasibility study and the rest of the study. In the feasibility study, 15 children aged 5-14 years who are scheduled to receive at least 2 vincristine administrations can be included. After the administration of vincristine, venous blood samples and finger prick blood samples will be taken to determine the vincristine concentrations. The samples will be shipped to and analyzed in the Netherlands to determine the vincristine concentration in each sample. Based on this, a dose advise will be given for subsequent vincristine administrations. This cycle will be repeated maximum 2 times but maximum 1 dose advice is given. Toxicity will be monitored by determination of the bilirubin, by questionnaires and by physical examination to check for signs of peripheral neuropathy. In the rest of the study, in which 85 children will be included, only finger prick samples will be taken. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05844670
Study type	Interventional
Source	Moi University
Contact	Aniek Uittenboogaard, MD
Phone	+31631293157
Email	a.uittenboogaard@amsterdamumc.nl
Status	Recruiting
Phase	Phase 4
Start date	April 20, 2023
Completion date	November 1, 2024

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT04262830` - Cancer Therapy Effects on the Heart
Not yet recruiting	`NCT06335745` - PediCARE Health Equity Intervention in High-Risk Neuroblastoma	N/A
Withdrawn	`NCT04719416` - Relaxation Therapy in Pediatric Oncology	N/A
Completed	`NCT01645436` - Physical Activity in Pediatric Cancer (PAPEC)	N/A
Completed	`NCT04409301` - Distress in the Pediatric Oncology Setting: Intervention Versus Natural Adaptation	N/A
Completed	`NCT04914702` - Feasibility and Comparison of Continuously Monitored Vital Signs in Pediatric Patients With Cancer.
Recruiting	`NCT05425043` - Granulocyte Transfusions After Umbilical Cord Blood Transplant	N/A
Recruiting	`NCT05071859` - Genetic Overlap Between Anomalies and Cancer in Kids in the Children's Oncology Group: The COG GOBACK Study
Recruiting	`NCT03241251` - Screening for Psychosocial Risk in Flemish Families of a Child With Cancer
Recruiting	`NCT05384288` - Response to Influenza Vaccination in Pediatric Oncology Patients
Completed	`NCT04586491` - The Effect of Oral Care Protocol on Prevention of Oral Mucositis in Pediatric Cancer Patients	N/A
Recruiting	`NCT05569512` - Uproleselan With Pre-Transplant Conditioning in Hematopoietic Stem Cell Transplantation for AML	Phase 1/Phase 2
Enrolling by invitation	`NCT05294380` - Determination of Sarcopenia Risk and Related Factors in Pediatric Oncological Patients
Completed	`NCT02665819` - Long Term Support for Pediatric Cancer Adult Survivors in Rhône-Alpes : Evaluation of Women Fertility.	N/A
Completed	`NCT02675166` - Getting Long-term Management of Adult Children Cured of Childhood Cancer in Rhône-Alpes
Not yet recruiting	`NCT05454163` - Post-radiotherapy Rhinosinusitis in Children
Terminated	`NCT02536183` - A Phase I Study of Lyso-thermosensitive Liposomal Doxorubicin and MR-HIFU for Pediatric Refractory Solid Tumors	Phase 1
Withdrawn	`NCT01828502` - Cotinine Feedback as an Intervention to Change Parental/Caregiver Smoking Behavior Around Children With Cancer	Phase 2
Completed	`NCT02032121` - Vascular Endothelial Inflammation and Dysfunction in Pediatric Long-term Cancer Survivors	N/A
Completed	`NCT03964259` - Reduced IV Fluids to Improve Clearance of HDMTX in Children w/Lymphoma or Acute Lymphoblastic Leukemia	Phase 1

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

CHildren Treated With Vincristine: A Trial Regarding Pharmacokinetics, DNA And Toxicity of Targeted Therapy In Pediatric Oncology Patients. — CHAPATI

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms