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Clinical Trial Summary

The objective of this study is to utilize all donated pediatric tumor tissues and cells obtained from autopsy to prospectively develop novel patient derived orthotopic xenograft (PDOX) mouse models as well as in vitro cell culture model systems for pediatric cancers, and also provide tissue samples to other researchers and organizations (eg, CBTN, DIPG Registry, COG).


Clinical Trial Description

The objective of this study is to utilize all donated pediatric tumor tissues and cells obtained from autopsy to prospectively develop novel patient derived orthotopic xenograft (PDOX) mouse models as well as in vitro cell culture model systems for pediatric cancers, and also provide tissue samples to other researchers and organizations (eg, CBTN, DIPG Registry, COG). This model system will then be subjected to 1) comprehensive histopathological and molecular characterizations during serial in vivo sub-transplantations; 2) cryopreserved for long term preservation of tumorigenicity; and 3) used for future biological studies and preclinical drug testing. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05120518
Study type Observational
Source Ann & Robert H Lurie Children's Hospital of Chicago
Contact Angela Waanders, MD
Phone 312-227-4090
Email [email protected]
Status Recruiting
Phase
Start date August 14, 2019
Completion date August 14, 2029

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