PCOS Clinical Trial
Official title:
Pretreatment With Myo-inositol in Hyperandrogenic PCOS Patients Undergoing ART: a Randomized Controlled Trial
A randomized controlled trial to evaluate whether pretreatment with myo-inositol can lower testosterone levels and improve clinical outcomes in hyperandrogenic PCOS patients undergoing ART
Status | Recruiting |
Enrollment | 134 |
Est. completion date | April 2020 |
Est. primary completion date | April 2020 |
Accepts healthy volunteers | No |
Gender | Female |
Age group | 18 Years to 40 Years |
Eligibility |
Inclusion Criteria: - Women aged 18-40 years - PCOS phenotypes A, B and C - Signed informed consent Exclusion Criteria: - Other relevant endocrine disorders - Contraindications to the use of gonadotropins - Endometriosis grade 3-4 - BMI > 35 |
Country | Name | City | State |
---|---|---|---|
Belgium | Universitair Ziekenhuis Brussel | Brussels |
Lead Sponsor | Collaborator |
---|---|
Universitair Ziekenhuis Brussel |
Belgium,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Serum testosterone level after 12 weeks of administration of Myo-Inositol | 2 years | ||
Secondary | Androstenedione and SHBG (Sex Hormone Binding Globulin) plasma levels after 12 weeks of administration of Myo-Inositol | 2 years | ||
Secondary | Number of mature oocytes | 2 years | ||
Secondary | Embryo quality | Day 3 embryos will be classified as transferable or cryopreservable/ 'good-quality embryos' (GQE) according to the criteria described by Van Landuyt et al. (2013). Blastocysts will be categorized according to Gardner et al. (1998) and Gardner and Schoolcraft (1999). | 2 years | |
Secondary | Implantation rate (%) | 2 years | ||
Secondary | Clinical pregnancy rate (%) | 2 years | ||
Secondary | Live birth rate in fresh cycle | 2 years | ||
Secondary | Cumulative live birth rate after 1 cycle | 2 years | ||
Secondary | Ovarian Hyperstimulation Syndrome rate | 2 years | ||
Secondary | Consumption of gonadotrophins | measurement in IU | 2 years | |
Secondary | Stimulation days | measurement in days | 2 years |
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT06101147 -
Effect of Vitamin D Supplementation on Testosterone Level in Women With Polycystic Ovary Syndrome
|
Phase 2 | |
Completed |
NCT02037672 -
PDE-4 Inhibitor Roflumilast and Polycystic Ovary Syndrome
|
Phase 4 | |
Completed |
NCT01833949 -
Unilateral Laparoscopic Diathermy Adjusted to Ovarian Volume
|
N/A | |
Completed |
NCT03608813 -
Myo-inositol, D-chiro-inositol and Glucomannan in PCOS
|
||
Not yet recruiting |
NCT05298657 -
The Angiotensin-Melatonin Axis in Poor and Hyper Responders for IVF Treatment
|
||
Completed |
NCT05951309 -
Myoinositol Treatment and Asprosin Levels in PCOS
|
N/A | |
Enrolling by invitation |
NCT04485403 -
The Effect of Ibuprofen on Women With PCOS.
|
Phase 2 | |
Not yet recruiting |
NCT03978013 -
Pomegranate Juice Effect on Oxidative Stress in Infertile Women During IVF Treatment
|
N/A | |
Completed |
NCT05843955 -
Non-alcoholic Fatty Liver Disease in Women With Polycystic Ovary Syndrome
|
||
Recruiting |
NCT05971849 -
Dampening the Reproductive Axis With Continuous Kisspeptin
|
Phase 1 | |
Recruiting |
NCT04597099 -
Androgen Blockade and Progesterone Augmentation of Gonadotropin Secretion
|
Early Phase 1 | |
Active, not recruiting |
NCT05206448 -
Randomized Controlled Trial of Combined Letrozole and Clomid (CLC II) Versus Letrozole Alone for Women With Anovulation
|
Phase 4 | |
Recruiting |
NCT02358421 -
Prediction of High Ovarian Response After Assisted Reproductive Techniques
|
N/A | |
Completed |
NCT04113889 -
Effects of Triple Drug Cocktail Therapy on Metabolic, Endocrine Alterations and Perceived Stress in Patients With Poly Cystic Ovary Syndrome
|
Phase 2 | |
Completed |
NCT04562883 -
Single vs. Group CAPA-IVM Culture of Cumulus-oocyte Complexes
|
N/A | |
Recruiting |
NCT03264638 -
A Clinical and Biological Research of Combined Chinese and Western Medicine in the Treatment of PCOS
|
Phase 2 | |
Completed |
NCT00594217 -
Determining How Quickly Progesterone Slows LH Pulse Frequency
|
Phase 1 | |
Recruiting |
NCT02024984 -
Luteal Phase Versus Follicular Phase Administration of Clomiphene Citrate in PCOS, A Randomized Controlled Trial
|
Phase 1 | |
Completed |
NCT01709942 -
Use of Degarelix in Controlled Ovarian Hyperstimulation (COH) Protocol for Women With PoliCystic Ovarian Syndrome (PCOS)
|
Phase 3 | |
Completed |
NCT01683513 -
Trial Comparing hCG Triggering Versus GnRH Agonist Triggering in PCOS Patients
|
Phase 4 |