Patients Who Needs Sedation After Head & Neck Surgery Clinical Trial
Official title:
The Optimal Dose of Sevoflurane Via Anaconda® in Post-operative Patient Underwent Head & Neck Surgery
Sedation in the ICUs is very common. There is no ideal sedative yet, so research has been
conducted to replace propofol and midazolam, which are the most commonly used sedatives in
ICUs, by inhalation anesthetics. The investigators will sedate the patients who undergo head
& neck surgery with tracheostomy for several days using sevoflurane, a kind of inhalation
agent, via anesthetic conserving device.
The objective of this study is to confirm the end-tidal sevoflurane concentration for
inducing moderate sedation (RASS -2~-3). In addition, the investigators compare the volatile
sedation with the IV(intravenous) sedation to see if the volatile sedation could reduce the
amount of post-operative opioid consumption.
- RASS: Richmond Agitation-Sedation Scale
- RASS: Richmond Agitation-Sedation Scale
When patients, who need mechanical ventilation for several days after head & neck surgery,
enters the ICU, the investigators induce moderate sedation (RASS -2~-3). End-tidal
sevoflurane (etSEVO) concentration is adjusted to 0.5Vol% within 30 minutes. Sedation level
is evaluated every 5 minutes. After 30 minutes, the investigators check that the sedation
goal is achieved.
Following the up & down method, if the moderate sedation (RASS -2~-3) or the deep sedation
(RASS -4~-5) is achieved at the etSEVO concentration of 0.5vol% after 30 minutes of sedation,
the next patient's target etSEVO concentration is reduced to 0.4vol%. On the contrary to
this, if only light sedation (RASS above -1) is achieved, the next patient's target etSEVO is
increased to 0.6vol%. This process is repeated to find the appropriate etSEVO concentration
at the beginning of sedation, which induces sedation of RASS -2~-3.
In retrospective analysis, the investigators compared the prospective study group with
propofol intravenous sedation group.
* RASS: Richmond Agitation-Sedation Scale
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