Patients Treated by Radiotherapy With < One Gy to the Brain Clinical Trial
Official title:
Etude Des séquelles Neurocognitives à Long Terme Des Faibles Doses de Radiation Chez 150 Patients traités Par radiothérapie Dans l'Enfance Pour un hémangiome cutané à l'Institut Gustave Roussy (IGR) Entre 1941 et 1973
Context: Studies that address specifically the neurocognitive consequences that can be
caused by low-dose radiation receiving during the childhood have still to be performed. In
this issue, we focus on an investigation with patients who have received radiotherapy for a
benign tumor (skin hemangioma), in France.
Patients and methods: More than 8300 children with a skin hemangioma were treated at Gustave
Roussy (Île-de-France) from 1941 to 1973 and a number of them have received radiotherapy.
These patients have been treated and followed by Gustave Roussy, so their clinical records
can be tracked with great accuracy and the ionizing radiation dose to the brain have been
estimated. From this patient cohort, the aim is to evaluate neurocognitive dysfunction or
disorder that can be caused by low-dose radiation to the brain (less than one Gray (Gy)). A
total of 150 patients is expected. They will be contacted by letter to explain the purpose
and methods of carrying out tests. Two groups will be analysed according to the received
ionizing radiation dose to the brain during the radiotherapy (exposed: 0.05 to 1 Gy, vs
unexposed: less than 0.05 Gy). Tests exploring several cognitive functions (memory,
arithmetic, orientation, etc.) will be used.
Expected results: We expect to describe the potential neurocognitive dysfunction or disorder
and to identify risk factors and brain structures whose lesions are responsible for the
neurocognitive dysfunction or disorder.
A therapeutic treatment will be proposed in the eventuality of screening of a neurocognitive
dysfunction or disorder.
CogRad is an interventional study designed within the European project called Cognitive and
Cerebrovascular Effects Induced by Low Dose Ionizing Radiation (CerebRad).
CerebRad is a collaborative European project funded in 2011 within the 7th European Union
(EU) framework programme, Nuclear Fission and Radiation Protection. CerebRad aims to
identify the potential cognitive and cerebrovascular risks of radiation doses below 100
milliGray (mGy) when delivered to a young child (pre- or postnatally).
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Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Screening