Patient-Controlled Analgesia Clinical Trial
Official title:
Comparison of Intravenous Patient-Controlled Analgesia With Different Background Infusion After Colorectal Surgery
In this study, the investigators investigated the efficacy, usefulness and analgesic consumption of three different patient-controlled analgesia(PCA) programmes:bolus dose alone without background infusion, bolus dose with low background infusion and bolus dose with high background infusion to evaluate postoperative analgesia for patients after laparoscopic colorectal surgery.
There have been many studies using patient-controlled analgesia (PCA) and opioids for
postoperative analgesia.Patient-controlled analgesia with opioids is now widely used after
surgery for the treatment of acute postoperative pain. This technique provides effective pain
treatment, adjusts the dose according to personal need and keeps plasma analgesic levels at a
constant level,but the incidence of opioid-induced side-effects still be reported
frequently.A proper PCA programme may increase efficiency of analgesic and decrease incidence
of analgesic-induced side-effects.
In this study, 90 patients who is undergoing elective laparoscopic colorectal surgery will be
randomly allocated into three groups (no background infusion group(Group B0),low background
infusion group(Group B1) and high background infusion group(Group B2)). Patients in all
groups will be given a patient-controlled analgesia (PCA) pump in post anesthetic recovery
unit (PACU) after surgery.The PCA programme of Group B0 is dezocine 0.6mg/kg, flubiprofen
3mg/kg, diluted into 120ml and administer at a background infusion of 0ml/h, and a bolus of
4ml, with a lock-out of 15min. The PCA protocol of Group B1 is dezocine 0.6mg/kg,flubiprofen
3mg/k diluted into 120ml and administer at a background infusion of 1ml/h, and a bolus of
2ml, with a lock-out of 15min.The PCA protocol of Group B2 is dezocine 0.6mg/kg,flubiprofen
3mg/k diluted into 120ml and administer at a background infusion of 2ml/h, and a bolus of
2ml, with a lock-out of 15min.
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