Patellofemoral Pain Syndrome Clinical Trial
Official title:
Neural Correlates of Knee Sensorimotor Control in Patients With Patellofemoral Pain Syndrome
Verified date | February 2024 |
Source | Emory University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
This study aims to determine the neural correlates of knee motor control in young females with patellofemoral pain (PFP). Each participant will attend a single study visit which may last up to 3 hours.
Status | Completed |
Enrollment | 15 |
Est. completion date | December 31, 2023 |
Est. primary completion date | December 31, 2023 |
Accepts healthy volunteers | No |
Gender | Female |
Age group | 7 Years to 40 Years |
Eligibility | Inclusion Criteria: - Diagnosed with patellofemoral pain (PFP) or anterior knee pain by a medical professional - Able to provide written consent Exclusion Criteria: - Any contraindications to MRI |
Country | Name | City | State |
---|---|---|---|
United States | Cincinanti Childrens Hospital Medical Center (CCHMC) | Cincinnati | Ohio |
United States | Emory Healthcare Sports Performance And Research Center (SPARC) | Flowery Branch | Georgia |
Lead Sponsor | Collaborator |
---|---|
Emory University |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Resting State Blood Oxygen Level Dependent (BOLD) Signal | Brain activity while the participant is lying still will be assessed as the BOLD signal obtained using fMRI. | Day 1 (during MRI session) | |
Primary | Blood Oxygen Level Dependent (BOLD) Signal During Flexion/Extension Movement | Brain activity while participants complete a combined knee and hip flexion/extension movement will be assessed as the BOLD signal obtained using fMRI. | Day 1 (during MRI session) | |
Primary | Blood Oxygen Level Dependent (BOLD) Signal During Quadriceps Contraction | Brain activity while participants complete a a quadriceps contraction task will be assessed as the BOLD signal obtained using fMRI. For the quadriceps contraction task, participants are asked to 'squeeze' their quadriceps while keeping the rest of their body still. | Day 1 (during MRI session) | |
Primary | Blood Oxygen Level Dependent (BOLD) Signal During Pain Inducing Tasks | Brain activity while participants complete pain inducing tasks will be assessed as the BOLD signal obtained using fMRI. The pain inducing tasks involve the researcher placing one hand above the participants' knee and applying intermittent pressure to their quadriceps and medial aspect of the patella. | Day 1 (during MRI session) | |
Secondary | Pain Scale Score | Participants reporting experiencing pain lasting longer than several days in the past two weeks complete a 4-item survey rating current, average, lowest and highest pain levels. Responses are given on a 5-point scale where 1 = no pain and 5 = worst pain possible. Total scores range from 4 to 20 and higher scores indicate greater pain. | Day 1 (during MRI session) | |
Secondary | Anterior Knee Pain Scale (AKPS) Score | Perceived movement dysfunction and disability related to knee pain is assessed using the Anterior Knee Pain (AKPS) scale. The AKPS has 13 items that are scored on scales of 0 to 5 or 0 to 10. Total scores range from 0 to 100 with 100 indicating the best knee function possible. | Day 1 (during MRI session) | |
Secondary | International Knee Documentation Committee (IKDC) Subjective Knee Evaluation Form Score | Perceived movement dysfunction and disability related to knee pain is assessed using the International Knee Documentation Committee (IKDC) Subjective Knee Evaluation Form. The IKDC is a 10-item, patient-completed tool which contains sections on knee symptoms, knee function, and sports activities. Scores range from 0 points (lowest level of function or highest level of symptoms) to 100 points (highest level of function and lowest level of symptoms). | Day 1 (during MRI session) | |
Secondary | Tampa Scale of Kinesiophobia (TSK) Score | Participant perceived movement dysfunction and disability related to knee pain is assessed using the Tampa Scale of Kinesiophobia (TSK). The TSK is a 17-item questionnaire assessing the fear of movement and re-injury. Responses are given on a 4-point Likert scale where 1 = strongly disagree and 4 = strongly agree. Total scores range from 14 to 68 where higher scores indicate greater concern of re-injury. | Day 1 (during MRI session) |
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