Patellofemoral Pain Syndrome Clinical Trial
Official title:
Intra-articular Hyaluronic Acid Injection for Therapy-resistant Patellofemoral Pain Syndrome: an Open-label, Randomized, Delayed-start Clinical Trial
Patellofemoral pain syndrome (PFPS) is the most common overuse injury seen in the athletic
population, particularly amongst runners. The standard of care treatment for PFPS is a
comprehensive active rehabilitation program. Eighty percent of patients with PFPS report
improvement in their symptoms with such a program. Unfortunately, the remaining twenty
percent fail to achieve adequate symptom relief with rehabilitation alone. Considering the
enormous number of individuals running for fitness, PFPS represents a significant challenge
to public health as the investigators strive to encourage active living in our society.
A relationship between PFPS and the development of patellofemoral osteoarthritis (PFOA) has
been suggested in scientific literature. Given that intra-articular viscosupplementation
(hyaluronic acid) injections have shown clinically significant symptom improvement in knee
osteoarthritis, and PFPS is likely on the same spectrum, the investigators propose a trial
for therapy-resistant PFPS.
Hyaluronic acid is a naturally occurring molecule found in the synovial fluid of freely
movable joints (such as the knee). It is believed to contribute to lubrication and
cushioning in these joints. The composition of synovial fluid within arthritic joints is
altered, resulting in reduced fluid viscosity and elasticity. One modern formulation of
hyaluronic acid is Hylan G-F 20 (Synvisc-One, Sanofi Canada). This treatment is offered as a
single injection and will be utilized in this clinical trial.
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
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