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Parvovirus B19 Infection clinical trials

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NCT ID: NCT04822090 Active, not recruiting - Clinical trials for Parvovirus B19 Infection

Parvovirus B19 Infection in Hereditary Hemolytic Anemias Patients

Start date: February 10, 2018
Phase:
Study type: Observational

Although many studies investigated the prevalence and manifestations of HPV-B19 infection in patients with sickle cell anemia (SCA), thalassemia, and hereditary spherocytosis (HS) separately, there is limited information about the extent to which HPV-B19 infection leads to severe complications and chronic infection.

NCT ID: NCT00379938 Terminated - Clinical trials for Parvovirus B19 Infection

B-19 Parvovirus Vaccine Study

Start date: August 2006
Phase: Phase 1/Phase 2
Study type: Interventional

This study investigates the safety and effectiveness of a preventative vaccine for parvovirus B-19 infection. Eighty-nine healthy adults ages 18-49, whose blood tests negative for B-19, will be enrolled. Participants will be randomly chosen to receive 1 of 4 possible vaccine types: low dose of the vaccine and an adjuvant (substance which assists with transfer of medication to body); high dose of the vaccine alone; high dose of the vaccine and an adjuvant; or saline (substance containing no medication). Participants will receive 3 vaccinations over a 6 month period and will be followed for 6 additional months. Blood samples will be taken at months 1, 2, 6, 7 and 12 to determine if antibody, protein produced by the body's immune system that recognizes and helps fight infections, has been formed to the vaccine. These tests measure vaccine efficacy, i.e., determine if the vaccine induces immunity. All participants will be followed closely for safety throughout the study.