Gait Analysis in Neurological Disease

Status Recruiting

Clinical Trial Summary

The purpose of this study is to investigate whether speed-dependent measures of gait can be identified in patients with neurological conditions that affect gait, particularly in subjects with parkinsonian disorders.

Clinical Trial Description

This study aims to determine whether the gait patterns in these subjects differ in predictable and quantifiable ways from those of age- and sex-matched healthy controls. This will be conducted by asking 40 Parkinsonian disorder subjects and 40 age-matched healthy control subjects to walk 9 trials over an 18 ft walkway embedded with pressure sensors at baseline, self-selected slower and faster speeds. In addition, the protocol aims to investigate whether clusters of gait patterns can be identified within subgroups of individuals with parkinsonian disorders with varying co-morbidities or treatment conditions as well as patients with ataxia syndromes. For this aim an additional 20 Parkinsonian disorder subjects need to be recruited. Patients with parkinsonism as defined by UK PD Brain Bank Criteria (n=60), subjects with acquired or inherited ataxic syndromes (n=10) and age- and sex matched controls (n=40) will be recruited. There is an optional second visit in the protocol during which approximately 20 subjects with Parkinsonian disorders, who are willing to come off antiparkinson medication and if applicable, off both medication and deep brain stimulation, are asked to walk an additional 9 trials. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02994719
Study type	Observational
Source	Beth Israel Deaconess Medical Center
Contact	Veronique Vanderhorst, MD PhD
Phone	617-667-0519
Email	vvanderh@bidmc.harvard.edu
Status	Recruiting
Phase
Start date	March 1, 2016
Completion date	June 20, 2025

View Details

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