Parkinson's Disease, Idiopathic Clinical Trial
Official title:
Clinical Trial to Study the Modification of the Pharmacokinetic Profile of Levodopa by the Fiber Plantago Ovata Husk
The purpose of this trial is to study the effect of the association levodopa/carbidopa with plantago ovata husk in Parkinson´s disease patients of recent diagnostic, that are being treated with levodopa/carbidopa.
Although the treatment with l-dopa is the election treatment for Parkinson´s disease, a high
number of patients develop motor complications, including, fluctuations and dyscinesia after
some years of treatment.
The origin of the fluctuations is not well established, but it could be attributed, al least
partially, a pharmacokinetics factors. So that, it could improve the answer and reduce the
adverse reaction if we reach more stable levels of L-dopa in the circulation. The first
experimental studies in animals showed that Plantago ovata husk has an influence in the
pharmacokinetics parameters of L-dopa, obtaining more stable levels.
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Allocation: Randomized, Endpoint Classification: Pharmacokinetics Study, Intervention Model: Crossover Assignment, Masking: Double-Blind, Primary Purpose: Treatment
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