Parkinson Disease(PD) Clinical Trial
Fatigue is one of the most common symptoms in individuals with Parkinson's Disease (PD).
Past research indicated that more than half of the individuals with PD demonstrated fatigue
symptom. The severity of fatigue was also correlated to the quality of life in individuals
with PD. Finding the contributions of the central and the peripheral factors to fatigue and
developing an effective training program for individuals with PD are very important.
Fatigue can be categorized into peripheral or central causes. The central fatigue and
voluntary activation failure originate from the decrease in motivation or the reduction of
the conduction within corticospinal tracts. Long term activation failure and central fatigue
will cause disuse of muscle and result in peripheral weakness and peripheral fatigue.
Quantifying the weighting of central versus peripheral factors contributing to the fatigue
in people with PD is important.
Most of the conventional strength and endurance training programs were based on the
researches of young groups. Almost no training program was design for enhancing the
voluntary activation level and relief the central fatigue. Seeking an appropriate training
program to enhance central activation is very important for individuals with PD who prone to
fatigue.
Previous studies have shown that increasing afferent input by peripheral electrical
stimulation (ES) at sensory threshold enhanced the plasticity of contralateral primary
sensory cortex, the excitability of corticospinal tracts, and the functional performance in
young adults. Combining afferent input with strength training was more effective than
strength training along. ES, which is easy to quantify the dose of afferent input, is a
feasible method to provide such training.
The purpose of this project is to investigate the effects of the combination of ES at
sensory threshold and strength training on voluntary activation in the individuals with PD.
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT02968433 -
The Stanford Parkinson's Disease Plasma Study
|
Phase 1 | |
Recruiting |
NCT06245174 -
A Smartphone Application for Neurology and Telemedicine
|
||
Completed |
NCT04193527 -
A Study to Evaluate the Diagnostic Efficacy of DaTSCAN™ Ioflupane (123I) Injection in Single Photon Emission Computed Tomography (SPECT) for the Diagnosis of Parkinsonian Syndrome (PS) in Chinese Patients
|
Phase 3 | |
Completed |
NCT04748263 -
Eye Gaze Strategies During Facial Emotion Recognition in Neurodegenerative Diseases: Links With Neuropsychiatric Disorders (EYE-ToM Study)
|
||
Recruiting |
NCT02656355 -
Gait Initiation Difficulty and Anticipatory Postural Adjustment (APA) Impairment in People With PD - Evaluation and Training
|
N/A | |
Completed |
NCT05113524 -
Effects of Dance on the Turning Characteristics of Patients With Parkinson's Disease
|
N/A |