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Parkinson Disease, Idiopathic clinical trials

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NCT ID: NCT05919160 Enrolling by invitation - Clinical trials for Parkinson Disease, Idiopathic

A High-density Microelectrode for Human Neuronal Recordings

Start date: June 2024
Phase: N/A
Study type: Interventional

The purpose of this study is to test the ability of a newly-designed electrode to measure the activity of individual nerve cells (neurons), and collections of nerve cells (local field potentials) in the brain. The study's main goals are to see how well this electrode works compared to standard electrodes and to validate its safety.

NCT ID: NCT05575479 Completed - Parkinson Disease Clinical Trials

PA Behavior and HRQoL in Parkinson's Disease Patients Patients: Role of Social Cognitive Variables

PDQ
Start date: August 2015
Phase:
Study type: Observational

The primary aim of the study will be to examine Social Cognitive Theory (SCT) correlates, of physical activity (PA) participation and health-related quality of life (HRQoL) in Parkinson's disease participants.

NCT ID: NCT04731246 Recruiting - Clinical trials for Parkinson Disease, Idiopathic

Video-oculography and Parkinson's Disease

Start date: July 7, 2021
Phase: N/A
Study type: Interventional

This study aims to study, in patient with Parkinson's disease, mild to moderate stage (according to Movement Disorder Society Clinical Diagnostic Criteria for Parkinson's Disease, Postuma et al., 2015): - the evolution of oculomotricity markers over time. - the correlation between neurological evaluations (motor and non-motor scores), neuropsychological evaluations (cognitive disorders) and oculomotricity evaluation, over a follow-up period of 7 years. - the impact of antiparkinsonian drugs on the evolution of oculomotricity assessment by video-oculography. - the value of oculomotricity assessment by video-oculography as an evolutionary marker of the disease.

NCT ID: NCT00244387 Completed - Clinical trials for Parkinson Disease, Idiopathic

Rotigotine Patch in Subjects With Advanced Stage, Idiopathic Parkinson's Disease Who Are Not Well Controlled on Levodopa

Start date: March 2004
Phase: Phase 3
Study type: Interventional

Male and female patients aged ≥ 30 years with advanced stage idiopathic Parkinson's disease, not well controlled on existing levodopa will take part in a research study at approximately 82 sites in Europe, Israel, South Africa, Australia and new Zealand. The purpose of the study is to evaluate the effectiveness, safety and tolerability of the rotigotine patch (SPM 962) at an individual patient's optimal dose for a period of 4 months Each patient who qualifies and chooses to participate in the study will receive either rotigotine, pramipexole, or placebo at gradually increasing doses over a period of up to 7 weeks, and then maintain their optimal dose for 4 months. The study clinic visits will include a medical history and physical exam, ECG, blood and urine sample collection, completion of various questionnaires, and completion of a diary to record the severity of their Parkinson's symptoms. Patients who complete the study may enroll in an extension trial and receive active study drug.