Detection of BRAF Mutation on FNAB From Papillary Thyroid Carcinoma

Status Completed

Clinical Trial Summary

Immunohistochemical detection of the BRAF-V600E mutation on pre-operative fine needle aspiration biopsy (FNAB) from patients suspected for papillary thyroid carcinoma, using the mutation specific antibody VE1.

Clinical Trial Description

The BRAF mutation is reported to be present in approximately 50% of papillary thyroid carcinomas (PTC). The mutation has been associated with poor prognosis and more advanced disease stage. Therefore, pre-operative detection of the BRAF-V600E mutation may be of clinical interest in order to individualize treatment of patients with BRAF positive PTC.

FNABs are performed immediately before the thyroid operation, and BRAF-V600E detection using VE1 is performed on clots. The VE1 stain is compared to the mutation status of the removed cancer or control tissue using the Cobas test. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02561533
Study type	Interventional
Source	University of Aarhus
Contact
Status	Completed
Phase	N/A
Start date	December 2014
Completion date	July 2017

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