Metastatic Renal Cell Carcinoma Clinical Trial
Official title:
A Phase l Open-Label, Dose Escalation and Cohort Expansion Study, to Assess the Safety and Activity of the Antibody-Drug Conjugate CDX-014 in Advanced or Metastatic Renal Cell Carcinoma (RCC) and Advanced or Metastatic Ovarian Clear Cell Carcinoma (OCCC)
This is a study to determine the safety of CDX-014 and effectiveness (how well the drug works).
CDX-014 is an antibody-drug conjugate that binds to a protein called TIM-1, which is found on
a high percentage of kidney cells that are clear or papillary and ovarian cancer cells that
are clear cell.
The study will enroll patients with advanced or metastatic renal cell carcinoma and ovarian
clear cell carcinoma to determine the safety and efficacy of CDX-014.
This study will include a Dose-Escalation Phase followed by a Cohort Expansion Phase
All patients enrolled in the study will be closely monitored to determine if there is a
response to the treatment as well as for any side effects that may occur.
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