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Cabozantinib in Advanced Pancreatic Neuroendocrine and Carcinoid Tumors

Pancreatic Neuroendocrine Tumor Clinical Trial

Official title:
An Open-Label, Phase II Study of Cabozantinib (XL184) in Advanced Pancreatic Neuroendocrine and Carcinoid Tumors

Clinical Trial Summary

Cabozantinib works by blocking the growth of new blood vessels that feed a tumor. In addition to blocking the formation of new blood cells in tumors, cabozantinib also blocks pathways that may be responsible for allowing cancers cells to become resistant to other "anti-angiogenic" drugs. Cabozantinib has been studied or is being study in research studies as a possible treatment for various types of cancer, including prostate cancer, brain cancer, thyroid cancer, lung cancer, and kidney cancer. In this research study, the investigators wish to learn if cabozantinib is effective in treating patients with pancreatic neuroendocrine and carcinoid tumors.

Clinical Trial Description

Subjects will take cabozantinib orally, once per day, in cycles of 28 days. During each cycle subjects will have the following procedures: - Physical examination, including measurement of weight and vital signs - Questions regarding any side effects - Blood sample (about 1 tablespoon) for routine laboratory tests of blood cell counts, blood chemistries, organ function and blood clotting - Blood sample (about 4 tablespoons) for research test to measure biomarkers to assess the response to study drug - Urine sample for routine urine tests to monitor health On Day 15 (beginning of week 3) during the first 3 cycles: - Physical examination, including measurement of weight and vital signs - Questions regarding any side effects - Blood sample (about 1 tablespoon) for routine laboratory tests of blood cell counts, blood chemistries, organ function and blood clotting - Blood sample (about 4 tablespoons) for research test to measure biomarkers to assess the response to study drug Subjects will receive a CT scan or MRI every two cycles (every two months) to evaluate disease. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01466036
Study type Interventional
Source Dana-Farber Cancer Institute
Contact
Status Completed
Phase Phase 2
Start date July 2012
Completion date December 2023
View Details
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