Gemcitabine, Ascorbate, Radiation Therapy for Pancreatic Cancer, Phase I

Status Active, not recruiting

Clinical Trial Summary

This is a phase 1 (first in man) study testing the safety of adding high dose ascorbate (vitamin C) to standard radiation and chemotherapy for treatment of pancreatic cancer.

Clinical Trial Description

This phase 1 study will test the safety of adding high dose ascorbate (vitamin C) to standard chemoradiation. The ascorbate is infused during external beam radiation therapy treatment. For patients eligible for this trial, standard treatment for their cancer includes radiation therapy combined with weekly gemcitabine (a chemotherapy). Participants will: - receive high doses of intravenous (IV) ascorbate during their daily radiation therapy treatments. Radiation treatments are given once a day, Monday through Friday. - have routine doctor's visits and be asked about any side effects they are experiencing. This is a phase 1 study that will evaluate the side effects of adding ascorbate to standard therapy. The dose given to a participant will be determined by how well other participants have tolerated ascorbate. ;

Study Design

Related Conditions & MeSH terms

Pancreatic Neoplasms

Clinical Trial Details

NCT number	NCT01852890
Study type	Interventional
Source	University of Iowa
Contact
Status	Active, not recruiting
Phase	Phase 1
Start date	January 2014
Completion date	January 2026

View Details

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