Pancreatic Neoplasms Clinical Trial
Official title:
A Phase I Trial of a Ketogenic Diet With Concurrent Chemoradiation for Pancreatic Cancer.
This study investigates if using a very low carbohydrate diet during combined chemotherapy and radiation therapy is safe and if it can be tolerated by patients.
Standard treatment for pancreatic cancer includes chemotherapy concurrent with radiation
therapy (chemoradiation).
This study is a phase I trial to determine the safety of dietary manipulation during
chemoradiation for pancreatic cancer. Specifically, pre-clinical data from mouse studies
indicates a ketogenic diet increases tumor cell killing.
Participants will:
- Utilize a specialized ketogenic diet designed by bionutritional services of the clinical
research unit. This diet begins 2 days before chemoradiation and continues through at
least 5 weeks of chemoradiation.
- Have blood drawn for research purposes weekly to determine measurements of oxidative
stress
- Have urine collected sporadically through the study to determine measurements of
oxidative stress
- Keep a diary of concomitant medications, side effects, and blood sugars
- Have follow-up to monitor for outcomes and overall survival
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