Phase II Study of PX-12 in Patients With Advanced Pancreatic Cancer

Status Terminated

Clinical Trial Summary

This study is being conducted to evaluate the clinical efficacy, biologic activity (inhibition of PX-12 target thioredoxin-1) and effects of an expired metabolite of PX-12 in patients with advanced pancreatic cancer.

Clinical Trial Description

In a Phase I trial, PX-12 demonstrated anti-tumor activity and pharmacodynamic activity across a wide dose range. At higher doses, one side effect of the agent was a garlic-like odor of an expired metabolite. This study is being conducted to evaluate the clinical efficacy, biologic activity (inhibition of PX-12 target thioredoxin-1) and effects of the expired metabolite at two dose levels of PX-12. This study will determine if the efficacy and biologic activity achieved at either of the two dose levels is sufficient to proceed to further studies without pushing to the maximally tolerated dose. ;

Study Design

Related Conditions & MeSH terms

Pancreatic Neoplasms

Clinical Trial Details

NCT number	NCT00417287
Study type	Interventional
Source	Seattle Genetics, Inc.
Contact
Status	Terminated
Phase	Phase 2
Start date	December 2006
Completion date	April 2009

View Details

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