Switch Maintenance in Pancreatic

Status Recruiting

Clinical Trial Summary

This study is being done to test the safety and effectiveness of combining domvanalimab (AB154), zimberelimab (AB122), and APX005M with pancreatic cancer that has spread to other parts of body. This research study involves immunotherapy. Immunotherapy triggers the body's immune system to fight cancer cells. The names of the study drugs involved in this study are: - Domvanalimab (also known as AB154) - Zimberelimab (also known as AB122) - APX005M

Clinical Trial Description

This is an open-label, Phase 1b/2, multicenter, randomized study evaluating the safety and efficacy of 'switch maintenance' combination immunotherapy (domvanalimab) zimberelimab and APX005M versus 'continuous maintenance' in patients with metastatic pancreatic cancer following 4-6 months of FOLFIRINOX The names of the study drugs involved in this study are: - Domvanalimab (also known as AB154) - Zimberelimab (also known as AB122) - APX005M The research study procedures include screening for eligibility and study treatment including evaluations and follow up visits. Participants will be randomized into one of two groups: - Arm A will receive domvanalimab, zimberelimab, and APX005M every two weeks through an infusion. - Arm B will receive leucovorin, fluorouracil, and irinotecan every two weeks through an infusion If you are in Arm B and the drugs stop working, participants may receive the drugs given in Arm A. Participants will receive study treatment as long the disease does not worsen or there are no serious side effects for a maximum of 26 cycles (2 years) and will be followed for 12 months after the discontinue the study drugs. It is expected that about 46 people will take part in this research study. This is a Phase I/II clinical trial. A Phase I clinical trial tests the safety of an investigational drug or drugs and also tries to define the appropriate dose of the investigational drug(s) to use for further studies. Phase II clinical trials test the safety and effectiveness of an investigational drug or drugs to learn whether the drug works in treating a specific disease. "Investigational" means that the drug is being studied. The U.S. Food and Drug Administration (FDA) has not approved domvanalimab, zimberelimab, or APX005M as a treatment for any disease. drug regimen. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05419479
Study type	Interventional
Source	Dana-Farber Cancer Institute
Contact	James Cleary, MD, PhD
Phone	617-632-6073
Email	James_Cleary@DFCI.HARVARD.EDU
Status	Recruiting
Phase	Phase 1/Phase 2
Start date	November 30, 2022
Completion date	September 30, 2028

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