Biological Effect of Warfarin on Pancreatic Cancer

Status Withdrawn

Clinical Trial Summary

This study aims to asses the effect of warfarin on markers of AXL pathway in patients with pancreatic adenocarcinoma.

Clinical Trial Description

There is emerging evidence from pre-clinical models that Axl activation is critical for the tumorigenesis and metastasis of pancreatic cancer. Warfarin is a readily available drug in the clinical setting and could be easily, safely, and quickly used in patients in combination with known cytotoxic chemotherapies to improve overall survival. Oral warfarin has been well tolerated in both prophylaxis for catheter-associated thrombosis and in advanced pancreatic cancer patients. The aim of this trial is to confirm the preclinical evidence that warfarin affects AXL pathway in patients with pancreatic cancer. This will validate the effect of escalating doses of warfarin on circulating biomarkers of AXL. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03536208
Study type	Interventional
Source	University of Texas Southwestern Medical Center
Contact
Status	Withdrawn
Phase	Early Phase 1
Start date	May 15, 2019
Completion date	June 2022

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