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Clinical Trial Summary

This study aims to asses the effect of warfarin on markers of AXL pathway in patients with pancreatic adenocarcinoma.


Clinical Trial Description

There is emerging evidence from pre-clinical models that Axl activation is critical for the tumorigenesis and metastasis of pancreatic cancer. Warfarin is a readily available drug in the clinical setting and could be easily, safely, and quickly used in patients in combination with known cytotoxic chemotherapies to improve overall survival. Oral warfarin has been well tolerated in both prophylaxis for catheter-associated thrombosis and in advanced pancreatic cancer patients. The aim of this trial is to confirm the preclinical evidence that warfarin affects AXL pathway in patients with pancreatic cancer. This will validate the effect of escalating doses of warfarin on circulating biomarkers of AXL. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03536208
Study type Interventional
Source University of Texas Southwestern Medical Center
Contact
Status Withdrawn
Phase Early Phase 1
Start date May 15, 2019
Completion date June 2022

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