Pancreas Neoplasms Clinical Trial
Official title:
Phase II Study: Docetaxel Plus Oxaliplatin as Second-line Therapy in Patients With Advanced Metastatic Pancreatic Cancer
The purpose of this study is to test a combination-therapy of oxaliplatin and docetaxel in patients with metastatic or locally advanced adenocarcinoma of the pancreas after failure of a palliative first line therapy.
Status | Recruiting |
Enrollment | 44 |
Est. completion date | December 2010 |
Est. primary completion date | December 2010 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Dated and signed informed concent - Histologically or cytologically proven metastatic or locally advanced adenocarcinoma of the exocrine pancreas (stadium UICC III/IV) - Presence of at least one measurable (according to RECIST criteria) marker lesion (primary tumor or metastasis) outside of an area that was previously subjected to radiation therapy - Failure of a palliative first line therapy of a metastatic or locally advanced adenocarcinoma of the exocrine pancreas due to: Progress within 3 months after a first-line therapy Discontinuation of a first-line therapy due to toxicity - Age >= 18 years - Karnofsky index > 60% - Expected live span > 12 weeks - Sufficient bone marrow reserve: Granulocytes >= 1.5 x 109/L and Platelets >= 100 x 109/L and Hemoglobin >= 9 g/L - Serum Bilirubin < 2 x upper normal limit or 2.5 x upper normal limit in case of hepatic metastasis (biliary drainage allowed) - AST/ALT < 2.5 x upper normal limit Exclusion Criteria: - Every other cancer or secondary cancer besides the basal cell carcinoma of the skin or the carcinoma in situ of the cervix uteri. Inclusion of patients with other types of cancer that were successfully treated and that did not relapse within the last 5 years is possible - Pregnancy or lactation - Patients able to reproduce that do not adhere to strict contraception - Presence of brain metastasis - Severe, uncontrolled infection - Preexisting peripheral neuropathy > grade I - Preexisting severe illnesses such as unstable coronary artery disease or uncontrolled cardiac arrhythmia - Justified disbelief in the compliance of the patient - Parallel participation in another clinical trial |
Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
Germany | Städtische Kliniken Esslingen | Esslingen | Baden Württemberg |
Germany | Klinik und Poliklinik für Innere Medizin I / Universitätsklinikum Halle | Halle | |
Germany | Universitätsklinikum Giessen und Marburg GmbH | Marburg | Hessen |
Germany | Klinikum Schwäbisch Gmünd | Mutlangen | Baden Württemberg |
Germany | Universitätsklinikum Ulm Klinik für Innere Medizin I | Ulm | Baden Württemberg |
Lead Sponsor | Collaborator |
---|---|
University of Ulm |
Germany,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | tumor response | 12/2009 and end of the study 12/2010 | Yes | |
Secondary | progression free survival | 12/2009 and end of study 12/2010 | No | |
Secondary | overall survival | 12/2009 and end of study 12/2010 | No | |
Secondary | Questionnaire for quality of life | every three weeks | No | |
Secondary | Questionnaire for clinical Benefit | every week | No | |
Secondary | toxicity / safety | all adverse events will be documented every week with their correlation to Oxaliplatin and Docetaxel | every week | Yes |
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