Clinical Trials Logo
  1. Home
  2. Pancreas Adenocarcinoma
  3. NCT04636788

Circulating Extracellular Exosomal Small RNA as Potential Biomarker for Human Pancreatic Cancer

Pancreas Adenocarcinoma Clinical Trial

Official title:
Diagnostic and Prognostic Values of EUS-FNA Specimens and Circulating Exosomal Small RNA in Patients With Pancreatic Cancer

Clinical Trial Summary

This study is for the verification of biomarkers for pancreatic cancer treatment using small RNA liquid biopsy, combined with EUS-FNA tissues.

Clinical Trial Description

CA19-9 is the FDA approved biomarker for the diagnosis of pancreatic cancer. However, the specificity of CA19-9 to differentiate between pancreatic cancer, cholangiocarcinoma, or other pancreatic lesions is not satisfying enough. Tumor cells secret abundant exosomes in the early stage. Circulating tumor cells are detected mainly in the advanced stage. Meanwhile, the role of non-coding RNA draws more and more attention in tumor area. Exosomes protect inside RNA from plasma RNase. Compared with long RNA, small RNA, including miRNA, snoRNA, tRNA, piRNA could exist more stably. By means of next-generation sequencing, we look forward to finding new exosomal small RNA biomarkers. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04636788
Study type Interventional
Source Huazhong University of Science and Technology
Contact Bin Cheng, Professor
Phone 13986097542
Email b.cheng@tjh.tjmu.edu.cn
Status Recruiting
Phase N/A
Start date November 1, 2020
Completion date November 1, 2022
View Details
See also
  Status Clinical Trial Phase
Recruiting NCT06065891 - Para-aortic Lymph Node Metastasis in Resectable Pancreatic Cancer N/A
Recruiting NCT05351983 - Patient-derived Organoids Drug Screen in Pancreatic Cancer N/A
Completed NCT01774162 - EUS-guided Fine Needle Biopsy With a New Core Histology Needle Versus Conventional Fine Needle Aspiration N/A
Recruiting NCT04164602 - The Occurence of Pancreatic Cancer Studied in Association With Newly Diagnosed Diabetes in the Elderly
Recruiting NCT05325281 - CPI-613 (Devimistat) in Combination With Chemoradiation in Patients With Pancreatic Adenocarcinoma Phase 1
Completed NCT05161013 - A Proof-of-Concept Study Evaluating LINFU™ N/A
Recruiting NCT05470920 - Genetic Testing Decision Aid N/A
Recruiting NCT04099134 - PACAREG: a Multicenter Registry Trial in Pancreatic Ductal Adencarcinoma
Recruiting NCT05518071 - FLUOPANC-trial - Fluorescence-guided Surgery of Pancreatic and Bileduct Tumors Using cRGD-ZW800-1 Phase 2
Withdrawn NCT04045730 - The Study of Gemcitabine Plus Nab-Paclitaxel in Combination With Pegvorhyaluronidase Alfa (PVHA; PEGPH20) and Pembrolizumab as Front-line Treatment for Metastatic Pancreatic Adenocarcinoma. Phase 2
Recruiting NCT06160596 - Analyzing and Solving Exceptional Long-term Survivors in Solid Tumors With Poor Prognosis
Recruiting NCT04435067 - Evaluation of Clinical, Radiomics and Molecular Features of Lung Metastasis in PDAC Patients (LUMACA Trial)
Recruiting NCT04571294 - Para-aortic Lymphnodes Removal During Upfront Pancreaticoduodenectomy N/A
Active, not recruiting NCT03472716 - The βIG-H3 Protein: a New Marker in PANCreatic Adenocarcinoma (BIGHPANC)
Completed NCT03532347 - Endoscopic Ultrasound Guided Tissue Sampling (The SharkBITE Study) N/A
Withdrawn NCT06090318 - Milademetan in Combination With Atezolizumab in Patients With Advanced Solid Tumors With CDKN2A Loss Phase 1/Phase 2
Not yet recruiting NCT06381882 - The Role of the Human Microbiome in Patients After Pancreatic Resection.
Recruiting NCT03544255 - Drug Screening of Pancreatic Cancer Organoids Developed From EUS-FNA Guided Biopsy Tissues
Recruiting NCT05340569 - Diagnostic Value of DWI-MRI for Detection of Peritoneal Metastases in High-risk Pancreatic Ductal Adenocarcinoma. N/A
Active, not recruiting NCT04241367 - Verification of Predictive Biomarkers for Pancreatic Cancer Treatment Using Multicenter Liquid Biopsy