Endogenous Modulation of Pain and Stretch Tolerance

Pain Threshold Clinical Trial

Official title:

Endogenous Modulation of Pain - the Tolerance to Stretch

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03886883
• Other study ID #: UniversityCND1
• Status: Completed
• Phase: N/A
• Start date: October 1, 2017
• Est. completion date: December 30, 2017

Study information

• Verified date: March 2019
• Source: University College of Northern Denmark
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study investigates the role of two endogenous inhibitory mechanisms; exercise-induced hypoalgesia (EIH) and a conditioning painful stimulus (CPM) on passive joint range of motion, passive resistive torque and pain sensitivity. The study is a randomized, repeated-measures cross-over study.

Description:

The increase in range of motion following stretching is related to changes in the tolerance to stretch. The mechanistic relationships behind these changes in subject sensation are however unknown but could be related to endogenous modulation of pain.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 19
• Est. completion date: December 30, 2017
• Est. primary completion date: December 30, 2017
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 45 Years

Eligibility

Inclusion Criteria:

• Eligibility for participation included the absence of any pain or other conditions that might affect the somatosensory system.

Exclusion Criteria:

• Substance abuse, History of neurological or mental disabilities, Lack of ability to comply with instructions, Delayed onset of muscle soreness.

Related Conditions & MeSH terms

• Pain Threshold

Intervention

Other:
• Exercise induced hypoalgesia (EIH)
An EIH response was induced by a 3-minute isometric contraction of the hand flexor muscles at 25% of maximal voluntary contraction (MVC).
• Static stretch (SS)
Two bouts of 30 seconds of static stretching (SS) of the knee flexors.
• Rest
The participants rested in a seated position for 10 minutes
• Conditioned pain modulation (CPM)
A CPM response was induced by way of the cold pressor test.

Locations

Country	Name	City	State
Denmark	University College of Northern Denmark	Aalborg

Sponsors (1)

Lead Sponsor	Collaborator
University College of Northern Denmark

Country where clinical trial is conducted

Denmark, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Knee extension range of motion	Passively induced knee extension range of motion was measured using the Biodex system 4 pro isokinetic dynamometer	Passive knee extension range of motion was measured as a baseline just prior to the induction of exercise-induced hypoalgesia (EIH), Static stretch (SS), Rest and a conditioning painful stimulus (CPM)
Primary	Knee extension range of motion	Passively induced knee extension range of motion was measured using the Biodex system 4 pro isokinetic dynamometer	Passive knee extension range of motion was measured 30 seconds after the induction of EIH, SS, Rest and CPM
Primary	Knee extension range of motion	Passively induced knee extension range of motion was measured using the Biodex system 4 pro isokinetic dynamometer	Passive knee extension range of motion was measured 10 minutes after the induction of EIH, SS, Rest and CPM
Secondary	Passive resistive torque	Passive resistive torque during the passive knee extension motion was measured using the Biodex system 4 pro isokinetic dynamometer.	Passive resistive torque was measured as a baseline just prior to the induction of EIH, SS, Rest and CPM
Secondary	Passive resistive torque	Passive resistive torque during the passive knee extension motion was measured using the Biodex system 4 pro isokinetic dynamometer.	Passive resistive torque was measured 30 seconds after the induction of EIH, SS, Rest and CPM
Secondary	Passive resistive torque	Passive resistive torque during the passive knee extension motion was measured using the Biodex system 4 pro isokinetic dynamometer.	Passive resistive torque was measured 10 minutes after the induction of EIH, SS, Rest and CPM
Secondary	Pressure pain thresholds	Pressure pain thresholds was measures using a handheld pressure algometer (Somedic AB, Hörby, Sweden.	Pressure pain thresholds were measured as a baseline just prior to the induction of EIH, SS, Rest and CPM
Secondary	Pressure pain thresholds	Pressure pain thresholds was measures using a handheld pressure algometer (Somedic AB, Hörby, Sweden.	Pressure pain thresholds were measured 30 seconds after the induction of EIH, SS, Rest and CPM
Secondary	Pressure pain thresholds	PRessure pain thresholds was measures using a handheld pressure algometer (Somedic AB, Hörby, Sweden.	Pressure pain thresholds were measured 10 minutes after the induction of EIH, SS, Rest and CPM