Chronic Pain After Operation for Breast Cancer

Status Enrolling by invitation

Clinical Trial Summary

The purpose of this study is to identify intraindividual as well as iatrogenic factors disposing for the development of chronic and acute pains after surgery for breast cancer in order to improve treatment and prevent the development of acute and chronic postoperative pains.

Clinical Trial Description

Surgery for breast cancer is followed by acute undesirable sequelae (pain, nausea, vomiting, psycho-social adaptation) and late sequelae with discomfort or more severe neuropathic pain problems in the surgical area due to nerve damage or adjuvant-/radiotherapy. The late sequelae occur in 30-50% of patients but the exact mechanisms (preoperative disposing factors, intraoperative nerve damage/inflammatory response), acute postoperative pain and psychosocial factors remain to be determined in large, detailed, well-described studies, including stratification to modern breast cancer treatment (sentinel node strategy/ radiotherapy/ chemotherapy). The present study will describe in detail preoperative psychosocial/genetic pain mechanisms, intraoperative technique, multi-modal anaesthesia and opioid-reduced analgesia with a detailed, early and late postoperative follow-up with neurophysiological assessment in the surgical area and randomised studies on preventive therapy. ;

Study Design

Intervention Model: Single Group Assignment, Masking: Single Blind (Subject), Primary Purpose: Prevention

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00739544
Study type	Interventional
Source	Rigshospitalet, Denmark
Contact
Status	Enrolling by invitation
Phase	Phase 0
Start date	August 2008
Completion date	March 2010

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT00385294` - Role of B2 Adrenergic Receptors in Labor Pain
Recruiting	`NCT05335057` - Effects of Social Presence and Perception in Virtual Reality on Pain (SPP)	N/A
Completed	`NCT03886883` - Endogenous Modulation of Pain and Stretch Tolerance	N/A
Completed	`NCT04919681` - Efficacy of Stretching on Pain Sensitivity	N/A
Completed	`NCT05904873` - Cold Press Test and Post Operative Pain Relationship	N/A
Completed	`NCT03713788` - Muscle Stretching - the Potential Role of Endogenous Pain Inhibitory Modulation on Stretch Tolerance	N/A
Completed	`NCT02828501` - Additive Effects of Combined Spinal Manipulations on Pain Pressure Threshold	N/A
Completed	`NCT01351363` - Prediction Of Post Operative Pain Following Arthroscopic Shoulder Surgery	N/A
Recruiting	`NCT05009433` - HIIT vs MICT During Pregnancy and Health and Birth Outcomes in Mothers and Children	N/A
Completed	`NCT00743119` - Comparison of the Analgesic Effects of Dronabinol and Smoked Marijuana in Daily Marijuana Smokers	Phase 2
Completed	`NCT04482075` - Relationship Between Pressure Pain Threshold and Pain Intensity, Affect and Disability in CLBP	N/A
Completed	`NCT01577992` - Evaluation of the Subjective and Objective Painful Threshold in Multiple System Atrophy Pain and Multiple System Atrophy	N/A
Completed	`NCT05989490` - The Effect of Stretching Intensity on Pain Sensitivity	N/A
Recruiting	`NCT05594511` - Mandibular Muscle Energy Technique in Patients With Mandibular Joint Pathology and Bruxism	N/A
Not yet recruiting	`NCT05252234` - Post SARS-Cov-2 Disease Anesthesia Events