Clinical Trials Logo

Clinical Trial Summary

This study will examine the acute effects of high intensity interval ergometry on peripheral concentrations of lactate and hydrogen ions, as well as cognitive function. Approximately 60 healthy, college-aged males will participate in the Wisconsin Card Sorting Task (WCST), a measure of executive function, two times over a span of two weeks. Prior to the WCST, participants will complete either a warm-up, a warm-up and high intensity interval exercise, or a stationary period. Changes in lactate, pH, and WCST score will be evaluated between and within groups in relation to the presence of the high intensity exercise stimulus.


Clinical Trial Description

The experimental protocol will be performed in three groups. Two of the three groups (HIT1 and HIT2) will counterbalance one another, meaning these participants will each receive the same level of treatment, but the treatments will occur in different sequence. The third group will serve as the control (CON). All qualified subjects will complete a consent form after receiving a detailed explanation of the experimental purpose and procedure by the investigator. Subjects qualify to participate in this study based upon the results of the preliminary health history record, ACSM risk assessment, and a 7-day activity recall form IPAQ. Following consent, participants will be randomized into one of three groups and will be scheduled three(3) lab sessions. A Subject Tracking Form will be used to monitor the progress of each subject.

All three groups begin the study with the same session protocol, constituting Day 1 (Baseline). This session will include baseline measurements of perceived effort (RPE), perceived pain (RPP), and affect (FS). These measures will be taken before and after the maximal oxygen uptake test scheduled on this day. Two single 15 mL blood samples (~1 tablespoon) will be drawn for baseline pH and lactate quantification. Blood draws (BD) are repeated for a total of 8 times throughout the study for a total of 120 mL of blood. During the two experimental sessions (Session 2 and Session 3) blood will be drawn 3 times each; prior to HIT or seated rest, immediately following HIT or seated rest, and following the Wisconsin Card Sorting Task (WCST). The seventh and eight blood draws will occur during baseline, immediately before and after the maximal oxygen uptake exercise test. Each group will participate in all 8 blood draws. A demonstration of the WCST and a review of the Tabata high-intensity interval training protocol (HIT) will also be given during this session. Session 1 includes a cardiovascular fitness assessment (relative VO2 test) and body fat assessment (Bioelectrical Impedence Analysis, or BIA).

The following two sessions, Day 3 (Session 2) and Day 17 (Session 3), will be different for each group. The first group, (HIT1), will complete a warm-up, HIT, and the WCST during Session 2. The next session, Session 3, will be scheduled no less than 14 days from Session 2 and includes a warm-up, a 5-minute stationary period, and the WCST. The second group, (HIT2), will complete the same protocols as HIT1, but will complete Session 2 and Session 3 in reverse order. The control group (CON) will not perform the warm-up or the HIT exercise before either WCST. This group will still have 14-days separating WCST attempts. A follow-up by email will be used to report the results of the WCST scores to each participant once all subjects have completed the study in its entirety. Instructions on how to receive compensation for participating in the study will also be provided in the follow-up.

Data will be analyzed using the current version of SPSS Statistics. A 2 (HIT, no HIT) x 3 (pre-, immediately post-, and delayed post- HIT) repeated measures ANOVA will be used to determine the affects of HIT on biophysiological functions (La, H+, RPP, RPE, and FS). A paired t-test will show changes in executive function due to HIT. A Pearson correlation will determine the influence of biophysiological factors on cognitive function and a 3 (HIT1, HIT2, CON) x 2 (time of WCST) mixed-model ANOVA will demonstrate the learning effects associated with the WCST over a 14-day period. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT02270528
Study type Interventional
Source Virginia Commonwealth University
Contact
Status Completed
Phase N/A
Start date October 2014
Completion date July 2018

See also
  Status Clinical Trial Phase
Completed NCT05731401 - Expressed Beliefs About the Cause of Pain in a Paediatric Population
Completed NCT05192902 - Pain Perception Following Computer-Controlled vs. Conventional Dental Anesthesia N/A
Recruiting NCT06129162 - Pain Perception Comparison of Computerized vs Conventional Injection Methods N/A
Withdrawn NCT03777137 - The Effect of Transcutaneous Magnetic Stimulation on Acute Pain.
Completed NCT06120062 - Effect of Swaddling and Inhaling Breast Milk Odour on the Pain and Comfort
Completed NCT04050384 - Effect of a Vibratory Stimulus on Mitigating Nociception-specific Responses to Skin Puncture in Neonates N/A
Completed NCT05440266 - Electrical Intra-cutaneous Half-sine Stimulation for Optimized Preferential C-fiber Activation N/A
Completed NCT06130267 - The Impact of an Immersive Digital Therapeutic Tool on Pain Perception N/A
Completed NCT03680625 - Virtual Reality vs Passive Distraction for Pain Management N/A
Completed NCT03744897 - Effect of Hypnosis Combined to Transcranial Direct Stimulation in Pain N/A
Completed NCT02949401 - Stress Inoculation Through Virtual Reality in the Pediatric Electrophysiology Laboratory N/A
Withdrawn NCT01145326 - Functional Microarray Augmentation of Skin Treatment With Lidocaine Phase 2/Phase 3
Completed NCT03985917 - Singing Groups for Seniors: Well-Being, Cognitive Function and Health N/A
Completed NCT04337814 - The Effect of Combined Oral and Topical Analgesics to Reduce Pain Perception During Electrodiagnostic Testing N/A
Recruiting NCT02991014 - Music-based Intervention for the Reduction of Pain N/A
Completed NCT02026258 - Efficiency of Piezotome-Corticision Assisted Orthodontics N/A
Active, not recruiting NCT03347721 - Does Lidocaine Gel Decrease Pain Perception in Women Undergoing Diagnostic Flexible Cystoscopy Phase 4
Completed NCT01862393 - Stimulus Phase Duration on Discomfort and Electrically Induced Torque of Quadriceps Femoris N/A
Completed NCT04396444 - Lavender Aromasticks for Pain Control N/A