Clinical Trials Logo

Clinical Trial Summary

Pain is a public health condition, which causes great functional disability. Its consequences pervade the personal and social life of the patient, leading to significant changes in their interpersonal relationships, including work, family and social spheres, reducing the ability to perform daily activities. Conventional treatment modalities have been show a very poor therapeutic response, in that most individuals end up becoming polymedicated patients and refractory to treatment. Among non-pharmacological techniques with promising analgesic effects it includes both the hypnotic analgesia and the transcranial stimulation of direct current (tDCS).


Clinical Trial Description

Introduction: Pain is a public health condition, which causes great functional disability. Its consequences pervade the personal and social life of the patient, leading to significant changes in their interpersonal relationships, including work, family and social spheres, reducing the ability to perform daily activities. Conventional treatment modalities have been show a very poor therapeutic response, in that most individuals end up becoming polymedicated patients and refractory to treatment. Among non-pharmacological techniques with promising analgesic effects it includes both the hypnotic analgesia and the transcranial stimulation of direct current (tDCS). Objective: To evaluate the synergistic effect of hypnotic analgesia associated with tDCS under metabolites parameters and pain levels in healthy individuals before a nociceptive stimulation pattern. Methods: it will be performed a blinded crossover sham controlled randomized clinical trial. It will be included 32 woman healthy subjects, Susceptible to the hypnosis technique according to the Scale of Hypnotic Susceptibility (WSGC) Scale of Hypnotic Scale score. aged 18 to 65. They will be allocated in one of the following groups: active tDCS + hypnotic analgesia, sham tDCS + hypnotic analgesia, hypnotic analgesia and tDCS . After a 7 days interval, the groups will be crossed in order to receive the opposite intervention of the first week. The primary endpoints will be the electrophysiological brain parameters, such as changes in the Theta, Alpha and Gamma waves, as measured by EEG. The secondary endpoints will be the level of pain, measured against nociceptive induced by the cold test and stimuli standardized pressure through algometry pressure and power down system modulatory pain, pain using the subject test - CPM - task. The intra and inter-group comparisons will be made by means of two-way ANOVA followed by Bonferroni. A p significance level of <0.05 was established. Expected results: This study hypothesizes that a synergistic effect of analgesic techniques in pain levels in healthy subjects compared to isolated character. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03744897
Study type Interventional
Source Hospital de Clinicas de Porto Alegre
Contact
Status Completed
Phase N/A
Start date July 18, 2017
Completion date November 1, 2018

See also
  Status Clinical Trial Phase
Completed NCT05731401 - Expressed Beliefs About the Cause of Pain in a Paediatric Population
Completed NCT05192902 - Pain Perception Following Computer-Controlled vs. Conventional Dental Anesthesia Phase 4
Recruiting NCT06129162 - Pain Perception Comparison of Computerized vs Conventional Injection Methods N/A
Completed NCT02270528 - Acute Effects of High Intensity Interval Exercise on Executive Function N/A
Withdrawn NCT03777137 - The Effect of Transcutaneous Magnetic Stimulation on Acute Pain.
Completed NCT06120062 - Effect of Swaddling and Inhaling Breast Milk Odour on the Pain and Comfort
Completed NCT04050384 - Effect of a Vibratory Stimulus on Mitigating Nociception-specific Responses to Skin Puncture in Neonates N/A
Completed NCT05440266 - Electrical Intra-cutaneous Half-sine Stimulation for Optimized Preferential C-fiber Activation N/A
Completed NCT06130267 - The Impact of an Immersive Digital Therapeutic Tool on Pain Perception N/A
Completed NCT03680625 - Virtual Reality vs Passive Distraction for Pain Management N/A
Completed NCT02949401 - Stress Inoculation Through Virtual Reality in the Pediatric Electrophysiology Laboratory N/A
Withdrawn NCT01145326 - Functional Microarray Augmentation of Skin Treatment With Lidocaine Phase 2/Phase 3
Completed NCT03985917 - Singing Groups for Seniors: Well-Being, Cognitive Function and Health N/A
Completed NCT04337814 - The Effect of Combined Oral and Topical Analgesics to Reduce Pain Perception During Electrodiagnostic Testing N/A
Recruiting NCT02991014 - Music-based Intervention for the Reduction of Pain N/A
Completed NCT02026258 - Efficiency of Piezotome-Corticision Assisted Orthodontics N/A
Active, not recruiting NCT03347721 - Does Lidocaine Gel Decrease Pain Perception in Women Undergoing Diagnostic Flexible Cystoscopy Phase 4
Completed NCT01862393 - Stimulus Phase Duration on Discomfort and Electrically Induced Torque of Quadriceps Femoris N/A
Completed NCT04396444 - Lavender Aromasticks for Pain Control N/A