Pain Measurement Clinical Trial
Official title:
Investigation of Analgesic and Anti-inflammatory Effects of Beta-adrenergic Antagonist Propranolol
Previous studies have shown that the beta-adrenergic system plays a role in processing pain and the expression of hyperalgesia. Recent studies have investigated the analgesic effects, and potential anti-hyperalgesic effects (using a model of opioid induced (OIH) hyperalgesia) of propranolol, a beta adrenergic antagonist. We plan to further investigate the analgesic effects, and the potential anti inflammatory effects, of propranolol and compare those effects to alfentanil, an opioid of known effect, and placebo
This study is a double blind-placebo controlled study in which subjects will be exposed to
propranolol infusion during one study day, the opioid alfentanil on another day, and placebo
infusion during a third study day. The infusion order will be randomized, and the
participant and individual conducting the pain testing will both be blinded to the
treatment.
Propranolol, alfentanil, and placebo infusions will be administered intravenously using a
computer-controlled infusion pump that can be set to accurately administer a target plasma
concentration of drug.
On one study day subjects will receive propranolol at a target concentration of 30ng/ml over
3 hours time. On another study day subjects will receive 100ng/ml alfentanil over 3 hours,
and on a third study day subjects will receive placebo (normal saline) using a
computer-controlled infusion paradigm.
Sites to be evaluated for response to propranolol and placebo will be established in 2 ways.
One will use ultraviolet B (UVB) exposure to create a "sunburn" causing inflammation and
pain. The other will be a model of acute injury using an array of micro-needles.
Means of evaluation of injured, and non-injured sites will be pain testing, interstitial
fluid sampling for detection of pro-inflammatory, and pro-nociceptive cytokines, and laser
doppler evaluation of tissue perfusion.
Subjects will be recruited using fliers. Interested participants will contact the study
team, their questions will be answered, and an appointment for screening will be made.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Basic Science
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02763059 -
Comparison Between Dexamethasone and Ibuprofen on Pain Prevention and Control Following Surgical Implant Placement
|
Phase 4 | |
| Completed |
NCT00524927 -
Safety and Efficacy of Methoxyflurane for Treatment of Incident Pain
|
Phase 4 | |
| Completed |
NCT04557982 -
Creating a Czech Version of the Simplified Faces Pain Scale and the Simplified Concrete Ordinal Pain Scale
|
||
| Completed |
NCT04124289 -
A Functional Pain Scale to Improve the Patient Experience
|
||
| Completed |
NCT03675945 -
Smartphone Evaluation of Postoperative Pain Profiles Following General Surgery in Children
|
||
| Completed |
NCT04451252 -
Predicting Response to Interventional Pain Management Techniques in Chronic Low Back Pain in a Prospective Cohort.
|
||
| Completed |
NCT03727373 -
Qualitative Study for Pain Measurement Using Innovative Health Technology
|
||
| Not yet recruiting |
NCT04555928 -
Measuring Pain Intensity in Older Patients: A Comparison of Five Scales
|
||
| Completed |
NCT06201195 -
Anterior Cutaneus Nerve and Distal Adductor Canal Block With USG for Total Knee Replacement Analgesia
|
N/A | |
| Completed |
NCT02603783 -
Esophageal capsaïcin Infusion and Mucosal Integrity
|
N/A | |
| Completed |
NCT04050384 -
Effect of a Vibratory Stimulus on Mitigating Nociception-specific Responses to Skin Puncture in Neonates
|
N/A | |
| Recruiting |
NCT05129007 -
Pain Monitoring of Herniated Disc Surgery Patients With Oura Ring
|
||
| Completed |
NCT05881551 -
Pain Assessment Via Force Measurement Using eEgg After Blockade of the Lumbar Facet Joints
|
N/A | |
| Completed |
NCT04888026 -
Impact on Pain Sensitivity of Clinical Interaction
|
N/A | |
| Recruiting |
NCT05223790 -
Assessment of the NIPE in Very Premature Infant Ventilated and Sedated in Neonatal Reanimation.
|
||
| Terminated |
NCT02630134 -
Device for Monitoring Pain During Intraoperative, Pre/Post Surgical Periods: Comparison With Standard of Care Monitoring
|
N/A | |
| Completed |
NCT05822336 -
Duration of IM Injection and Pain Intensity
|
N/A | |
| Completed |
NCT02919891 -
Relationship of Intra-Epidermal Nerve Fibre Density (IENFD) and Structure to Chronic Post-Mastectomy Pain Syndrome (PMPS)
|
||
| Completed |
NCT04392180 -
COA-APTIC Caregiver Concept Elicitation Study
|
||
| Not yet recruiting |
NCT06431802 -
Construction and Application of the Visualization Training Platform Based on a Multimodal Standardized Dataset for Pain Assessment in Critically Ill Children
|
N/A |