Pain Insensitivity, Congenital clinical trials

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

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NCT ID: NCT02696746 Recruiting - Chronic Pain Clinical Trials

Painful Channelopathies Study

PCS

Start date: February 2012
Phase:
Study type: Observational

To understand the pathophysiological basis of heritable pain syndromes. This will consist of a number of components: - Determine the genetic basis for heritable pain syndromes. - Investigate the pain symptoms, psychological co-morbidity and quality of life in patients with heritable pain syndromes. - Use quantitative sensory testing to investigate abnormalities in sensory processing. - Use imaging modalities to investigate the neural correlates of pain perception in heritable channelopathies. - In select patients to perform skin biopsy to determine if there has been any damage to C-fibres. - To perform skin biopsy in order to culture fibroblasts and neural crest stem cells for future studies into the molecular basis of altered pain perception. - To use neurophysiological tests, the axon reflex, and conditioning challenges to determine how peripheral nerves, in heritable channelopathies and unusual pain syndromes, have been altered. - Microneurographic recordings for directly detecting the function of pain fibres in peripheral nerves. Knowledge gained from the study will be used to aid the further development of genetic testing and specific pain questionnaires for the diagnosis of heritable pain syndromes secondary to channelopathies. - Ultimately better knowledge of underlying pathophysiology in these heritable pain conditions may inform the development of novel treatments.