Developing an Objective Measure of Experienced Pain

Status Completed

Clinical Trial Summary

Pain is a public health challenge around the world. However, there is no single standardized measure of pain, to the point that the estimated prevalence of chronic pain in adults ranges between 2% and 64% depending on the methods and definitions used. Existing measures of pain are known to present several problems and results can be hardly compared between people. The investigators propose and empirically validate a new, simple method to measure experienced pain in clinical trials. The method provides an objective, cardinal measurement of experienced pain which is comparable between people and the investigators test whether it is better able to measure experienced pain than existing procedures. The investigators test the new method in healthy participants using standard protocols (electrical and heat stimuli). The investigators also aim to validate the measure using a causal manipulation which relies on the administration of a topical analgesic product compared to a placebo.

Clinical Trial Description

The aim of this study is to establish and validate the proposed method of measuring pain using different pain stimuli. The investigators correlate these measurements with physiological data such as skin-conductance, heart-rate variability, pupil dilation, and with established measures of pain such as Numeric rating scale (NRS), Visual analog scale (VAS), general Labeled Magnitude Scale (gLMS). In addition, the investigators study the test-retest reliability of our measure of pain and its ability to capture a reduction in experienced pain due to a topical analgesic product compared to a placebo treatment. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05415423
Study type	Interventional
Source	University of Zurich
Contact
Status	Completed
Phase	N/A
Start date	June 6, 2022
Completion date	September 26, 2022

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT05396820` - Adaptation of the Motor System to Experimental Pain	N/A
Completed	`NCT04356963` - Adjunct VR Pain Management in Acute Brain Injury	N/A
Recruiting	`NCT06350084` - Effect of Mother's Touch and Nurse's Therapeutic Touch on Pain Level and Crying Time During Heel Blood Collection	N/A
Completed	`NCT04080037` - Assessing Opioid Care Practices Using CPV Patient Simulation Modules	N/A
Recruiting	`NCT05458037` - RCT of Pain Perception With Fast and Slow Tenaculum Application	N/A
Completed	`NCT04571515` - Dose-Response Study of MR-107A-01 in The Treatment of Post-Surgical Dental Pain	Phase 2
Completed	`NCT06005480` - Understanding Rebound Pain After Regional Anesthesia Resolution in Healthy Volunteers	Phase 1
Active, not recruiting	`NCT04850079` - EHR Precision Drug Treatment in Neonates
Completed	`NCT03271151` - Effect of Duloxetine on Opioid Use After Total Knee Arthroplasty	Phase 4
Completed	`NCT03272139` - Interscalene Block Versus Superior Trunk Block	Phase 4
Recruiting	`NCT05383820` - Effect of Paracetamol and Ketorolac on RANK-L Levels in Patients Starting Orthodontic Treatment	Phase 4
Completed	`NCT04851353` - Multiple Sensory Interventions On Infants' Pain and Physiological Distress During Neonatal Screening Procedures	N/A
Completed	`NCT03280017` - Ketamine With Multilevel Paravertebral Block for Post Video-assisted Thoracic Surgery Pain	Phase 4
Completed	`NCT04280796` - Changes in Affective Pain Processing in Human Volunteers	N/A
Not yet recruiting	`NCT04491630` - COping With PAin Through Hypnosis, Mindfulness and Spirituality	N/A
Not yet recruiting	`NCT04523623` - Pain Control Differences Between Oxycodone and Ibuprofen in Children With Isolated Forearm Injuries	N/A
Not yet recruiting	`NCT04062513` - Olfactive Stimulation Interventions With Mothers' Milk on Preterm Pain Response	N/A
Withdrawn	`NCT03137017` - A Comparison of Plasma Concentrations of Hydrocodone and Acetaminophen After Administration of a New and a Marketed Tablet Formulation Under Fasted and Fed Conditions in Healthy Adults	Phase 1
Withdrawn	`NCT03137030` - A Comparison of Plasma Concentrations of Hydrocodone and Acetaminophen After Administration of Different Amounts of Tablets of a New and a Marketed Tablet Formulation in Healthy Adults	Phase 1
Completed	`NCT04659395` - How to Develop a Training Program for Nurses in Ultrasound Guided Femoral Nerve Block	N/A