The Effects of Three Different Ultrasound-guided Nerve Blocks in VATS

Pain, Acute Clinical Trial

Official title:

The Effects of Ultrasound-guided Mid-point Transverse Process to Pleura Block, Erector Spinae Plane Block and Paravertebral Block on Postoperative Pain in Video-assisted Thoracic Surgery

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT04829409
• Other study ID #: TJMZK20210301
• Status: Recruiting
• Phase: N/A
• Start date: April 5, 2021
• Est. completion date: December 2022

Study information

• Verified date: April 2022
• Source: Huazhong University of Science and Technology
• Contact: Wenlong Yao, MD
• Phone: 86-27-83663173
• Email: wlyao82[@]126.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Ultrasound-guided mid-point transverse process to pleura block, erector spinae plane block and paravertebral block are three different methods of nerve block, used for relieving postoperative pain in thoracic anesthesia. This study is to compare them on block effects, postoperative pain and analgesic consumption in video-assisted thoracic surgery.

Description:

Ultrasound-guided nerve block is an important part of multi-mode analgesia to decrease the consumption of opioids. Thoracic paravertebral block is considered as an ideal regional analgesic choice for video-assisted thoracic surgery, but it still has some side effects, such as pneumothorax, vascular injury, especially for novices. Recent years, ultrasound-guided mid-point transverse process to pleura block and erector spinae plane block are reported for thoracic surgery. The insertion depth in these two methods is more superficial than traditional paravertebral block. They could have less side effects. Therefore, we design a randomised control study to compare them on block effects, postoperative pain and analgesic consumption in video-assisted thoracic surgery.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 90
• Est. completion date: December 2022
• Est. primary completion date: October 2022
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 70 Years

Eligibility

Inclusion Criteria:

• selective lobetomy under VATS

• ASA classfication 1-3

Exclusion Criteria:

• history of thoracic surgery

• double lateral VATS

• allergy to local anesthetics

• coagulation disorders

• severe heart diseases, hepatic or renal insufficiency

• a history of chronic pain or chronic opioid use

• psychiatric disease or uncooperative

• BMI>28 kg/m2

• VATS transfered to open thoractomy

Related Conditions & MeSH terms

• Acute Pain
• Nerve Block
• Pain, Acute
• Thoracic Anesthesia

Intervention

Procedure:
• Paravertebral block
Patients receive ultrasound-guided paravertebral block
• ESP block
Patients receive ultrasound-guided erector spinae plane (ESP) block
• MTP block
Patients receive ultrasound-guided mid-point transverse process to pleura (MTP) block

Locations

Country	Name	City	State
China	Tongji Hospital, Huazhong University of Science and Technology	Wuhan	Hubei

Sponsors (1)

Lead Sponsor	Collaborator
Huazhong University of Science and Technology

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	block level	measured by pin-prick at clavicle midline	20 minutes after block
Other	intraoperative analgesic comsumption	the dose of sufentanil, remifentanil	intraoperative, from induction to emergence from anesthesia
Primary	postoperative morphine consumption	The dose is according to the record from PCA pump	postoperative 24 hours
Secondary	Pain score at rest	measured by VAS (0-10)	at 0, 8, 24 hour after surgery
Secondary	Pain score while coughing	measured by VAS (0-10)	at 0, 8, 24 hour after surgery