Pain, Acute Clinical Trial
Official title:
Inhaled Versus Intravenous Opioid Dosing for the Initial Treatment of Severe Acute Pain in the Emergency Department
Prospective single-blind, multicenter, national, randomized, controlled trial in 15 Emergency
Department to compare two ways of morphine titration. The eligible patient is included
immediately after his arrival in the Emergency Department, after being questioned by the
triage nurse about the presence and the intensity of pain, when the VAS is greater than 70
(or EN>7) and after written consent.
After installation into the examination room, patient is randomized in one of two parallel
groups (stratified by sex and center using software) and receives one of the two treatments,
either inhaled morphine + IV placebo or IV morphine+ inhaled placebo (control group).
In both groups, titration is defined by a dose of repeated boluses as long as the relief is
not achieved (VAS> 30 or EN >3) and the criteria to stop titration are not met.
A 5 minutes time interval between the boluses is chosen. Each aerosol takes 5 minutes at a
constant air flow, aerosol mask, plastic tubing and PVC transparent tank are used.
Thus patient receives a maximum of 3 aerosol (one aerosol every 10 minutes) and a maximum of
6 IV injections (one injection every 5 minutes) The stopping criteria, except pain relief,
are linked to the occurrence of side effects and specific cares are described into the
protocol (in case of severe ventilatory depression naloxone titration is provided). Exit
criteria from the emergency room and from the hospital are defined. An information sheet is
delivered.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT05396820 -
Adaptation of the Motor System to Experimental Pain
|
N/A | |
| Completed |
NCT04356963 -
Adjunct VR Pain Management in Acute Brain Injury
|
N/A | |
| Recruiting |
NCT06350084 -
Effect of Mother's Touch and Nurse's Therapeutic Touch on Pain Level and Crying Time During Heel Blood Collection
|
N/A | |
| Completed |
NCT04080037 -
Assessing Opioid Care Practices Using CPV Patient Simulation Modules
|
N/A | |
| Recruiting |
NCT05458037 -
RCT of Pain Perception With Fast and Slow Tenaculum Application
|
N/A | |
| Completed |
NCT04571515 -
Dose-Response Study of MR-107A-01 in The Treatment of Post-Surgical Dental Pain
|
Phase 2 | |
| Completed |
NCT06005480 -
Understanding Rebound Pain After Regional Anesthesia Resolution in Healthy Volunteers
|
Phase 1 | |
| Active, not recruiting |
NCT04850079 -
EHR Precision Drug Treatment in Neonates
|
||
| Completed |
NCT03272139 -
Interscalene Block Versus Superior Trunk Block
|
Phase 4 | |
| Completed |
NCT03271151 -
Effect of Duloxetine on Opioid Use After Total Knee Arthroplasty
|
Phase 4 | |
| Recruiting |
NCT05383820 -
Effect of Paracetamol and Ketorolac on RANK-L Levels in Patients Starting Orthodontic Treatment
|
Phase 4 | |
| Completed |
NCT04851353 -
Multiple Sensory Interventions On Infants' Pain and Physiological Distress During Neonatal Screening Procedures
|
N/A | |
| Completed |
NCT03280017 -
Ketamine With Multilevel Paravertebral Block for Post Video-assisted Thoracic Surgery Pain
|
Phase 4 | |
| Completed |
NCT04280796 -
Changes in Affective Pain Processing in Human Volunteers
|
N/A | |
| Not yet recruiting |
NCT04491630 -
COping With PAin Through Hypnosis, Mindfulness and Spirituality
|
N/A | |
| Not yet recruiting |
NCT04523623 -
Pain Control Differences Between Oxycodone and Ibuprofen in Children With Isolated Forearm Injuries
|
N/A | |
| Not yet recruiting |
NCT04062513 -
Olfactive Stimulation Interventions With Mothers' Milk on Preterm Pain Response
|
N/A | |
| Withdrawn |
NCT03137030 -
A Comparison of Plasma Concentrations of Hydrocodone and Acetaminophen After Administration of Different Amounts of Tablets of a New and a Marketed Tablet Formulation in Healthy Adults
|
Phase 1 | |
| Withdrawn |
NCT03137017 -
A Comparison of Plasma Concentrations of Hydrocodone and Acetaminophen After Administration of a New and a Marketed Tablet Formulation Under Fasted and Fed Conditions in Healthy Adults
|
Phase 1 | |
| Completed |
NCT04659395 -
How to Develop a Training Program for Nurses in Ultrasound Guided Femoral Nerve Block
|
N/A |