Cardiac ResynchrOniSation Via Stimulation of the LEFT Bundle in AF Patients. — CROSS-LEFT-AF  

Pacing-Induced Cardiomyopathy Clinical Trial

Official title: Cardiac ResynchrOniSation Via Stimulation of the LEFT Bundle in AF Patients.

Status Recruiting

Clinical Trial Summary

Permanent ventricular pacing may be complicated with ventricular dyssynchrony and subsequent pacing-induced cardiomyopathy. We hypothesized that left bundle branch area pacing may prevent the development of pacing-induced cardiomyopathy in patients with permanent atrial fibrillation requiring permanent ventricular pacing. Patients with permanent atrial arrhythmia with an indication of cardiac pacing and atrioventricular junction ablation will be prospectively enrolled. They will undergo the implantation of a single-chamber pacemaker with left bundle branch area pacing, and then atrioventricular junction ablation. They will be prospectively followed during 6 months.

Clinical Trial Description

Patients with permanent atrial arrhythmia with an indication of cardiac pacing and atrioventricular junction ablation will be prospectively enrolled. They will undergo the implantation of a single-chamber pacemaker with left bundle branch area pacing confirmed according to electrocardiographic parameters. Atrioventricular node ablation will be performed the following day through a femoral venous approach. Perioperative data and potential complications will be collected. Patients will be prospectively followed during 6 months. They will have clinical examination, 12-lead ECG, and an echocardiography. ;

Related Conditions & MeSH terms

• Cardiomyopathies
• Pacing-Induced Cardiomyopathy

• NCT number: NCT05162716
• Study type: Observational [Patient Registry]
• Source: University Hospital, Tours
• Contact: Nicolas CLEMENTY
• Phone: +33618072141
• Email: nclementy@yahoo.fr
• Status: Recruiting
• Start date: May 1, 2020
• Completion date: October 30, 2022