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His Bundle Pacing Versus Right Ventricular Pacing — His-PACE  

Pacing-Induced Cardiomyopathy Clinical Trial

Official title:
His Bundle Pacing Versus Right Ventricular Pacing: a Randomized Crossover Study (His-PACE)

Clinical Trial Summary

This study will randomize cross-over periods of 6 months of right ventricular pacing and His bundle pacing in patients with baseline left ventricular ejection fraction (LVEF)>40%. The primary outcome measure is LVEF.

Clinical Trial Description

Monocentric, randomized, double-blind comparative crossover clinical study. Patients with a standard pacing indication with >20% ventricular pacing, with a baseline LVEF >40%, implanted with a functioning His bundle lead and a backup right ventricular lead, will be randomized to 6-months periods of right ventricular pacing and of His bundle pacing. The primary outcome is LVEF assessed by gated Equilibrium Radionuclide Angiography. Secondary outcomes are diastolic function, New York Heart Association (NYHA) functional class, quality of life, 6-minute walk test, heart failure hospitalisations and device electrical parameters. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04672408
Study type Interventional
Source University Hospital, Geneva
Contact Haran Burri, MD
Phone +41223727200
Email haran.burri@hcuge.ch
Status Not yet recruiting
Phase N/A
Start date February 2021
Completion date June 2023
View Details
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Active, not recruiting NCT06008340 - Effect of Right Ventricle Lead Position on The Psychological Aspects of Patients With A Dual Chamber Pacemaker