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Clinical Trial Summary

This is an open-label, pilot study, to characterize oxytocin response to a single dose of oral Estrogen-progestin in patients with arginine-vasopressin deficiency compared to healthy controls. The association between oxytocin levels and measures of psychopathology (i.e., anxiety and depression) and quality of life across groups will be examined. We hypothesize that: 1. Salivary and blood oxytocin response to Estrogen-progestin will be lower in arginine-vasopressin deficiency compared to healthy control. 2. Lower salivary and blood oxytocin levels will be associated with more severe symptoms of anxiety, depression, and social emotional difficulties as well as lower quality of life.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT06460948
Study type Interventional
Source Massachusetts General Hospital
Contact Francesca Galbiati, MD
Phone 617-726-3870
Email fgalbiati@bwh.harvard.edu
Status Not yet recruiting
Phase Early Phase 1
Start date June 2024
Completion date June 2026

See also
  Status Clinical Trial Phase
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Completed NCT04902235 - Identification and Clinical Relevance of an Oxytocin Deficient State (CRH Study) Phase 4
Completed NCT04427410 - The Relationship Between Oxytocin Level and Postpartum Depression
Completed NCT05319301 - Identification and Clinical Relevance of an Oxytocin Deficient State (Melatonin Study) N/A