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NCT02834845 Clinical Trial

Comparison of Volatile Anesthetics on Cerebral Oxygenation During Controlled Hypotension

Oxygen Saturation Clinical Trial

Official title:
Comparison of Effects of Sevoflurane and Desflurane on Cerebral Oxygenation During Controlled Hypotension

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT02834845
Other study ID # 2016Sept
Secondary ID
Status Completed
Phase Phase 4
First received
Last updated
Start date June 2016
Est. completion date August 2016

Study information
Verified date August 2020
Source Ufuk University
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Controlled hypotension is a preferred method for reducing surgical bleeding during septoplasty operations however, the level of hypotension and bradycardia should not disrupt cerebral oxygenation. On this account, the investigators aim to investigate the effects of different volatile anesthetics combined with a short-acting opioid on cerebral oxygenation during controlled hypotension using near infrared spectroscopy.

Recruitment information / eligibility
Status Completed
Enrollment 95
Est. completion date August 2016
Est. primary completion date August 2016
Accepts healthy volunteers No
Gender All
Age group 18 Years to 65 Years
Eligibility Inclusion Criteria:

- Patients in American Society of Anesthesiology (ASA) classification I and II

- Patients undergoing elective septoplasty operation

Exclusion Criteria:

- Patients in ASA classification III and higher

- Emergency surgery

- Patients in New York Heart Association classification III-IV

- Patients with known allergy to drugs used in the study

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• Sevoflurane
Sevoflurane %2-3 for general anesthesia maintenance
• Desflurane
Desflurane %6-8 for general anesthesia maintenance

Locations
Country Name City State
Turkey Ufuk University Hospital Ankara

Sponsors (1)
Lead Sponsor Collaborator
Ufuk University

Country where clinical trial is conducted

Turkey, 

Outcome
Type Measure Description Time frame Safety issue
Primary Cerebral oxygen saturation as measured by Near Infrared Spectroscopy The effect of sevoflurane and desflurane on NIRS values Duration of surgery
Secondary Total remifentanil consumption as measured in micrograms Duration of surgery
Secondary The effect of anesthetics on hemodynamic variables The effects of sevoflurane and desflurane on mean arterial pressure Duration of surgery
Secondary The effect of anesthetics on hemodynamic variables The effects of sevoflurane and desflurane on heart rate Duration of surgery
Secondary The effect of anesthetics on hemodynamic variables The effects of sevoflurane and desflurane on bispectral index Duration of surgery
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