Oxidative Stress Clinical Trial
Official title:
The Effect of Alpha-tocopherol in Hemolysis and Oxidative Stress Marker on the Red Cell
The accumulation of unpaired α-globin chains in β-thalassemia major patients may clinically create ineffective erythropoiesis, hemolysis, and chronic anemia. Multiple blood transfusions and iron overload cause cellular oxidative damage. However, α-tocopherol, an antioxidant, has been known as a potent scavenger of lipid radicals in the red cell membrane of β-thalassemia major patient. By this randomized controlled trial, the investigators would like to evaluate the effects of α-tocopherol in hemolysis and oxidative stress on the red cell membrane of β-thalassemia major.
Background: The accumulation of unpaired α-globin chains in β-thalassemia major patients may
clinically create ineffective erythropoiesis, hemolysis, and chronic anemia. Multiple blood
transfusions and iron overload cause cellular oxidative damage. However, α-tocopherol, an
antioxidant, has been known as a potent scavenger of lipid radicals in the red cell membrane
of β-thalassemia major patients.
Purpose: To evaluate the effects of α-tocopherol in hemolysis and oxidative stress on the red
cell membrane of β-thalassemia major.
Methods: In this randomized controlled trial, the investigators allocated subjects in the
placebo and α-tocopherol groups. Doses of α-tocopherol were based on the recommendation of
Institute of Medicine: 4-8 years old 200 mg/day; 9-13 years old 400 mg/day; 14-18 years old
600 mg/day. Hemolysis, oxidative stress, and antioxidant variables were evaluated before and
after 4 weeks of consuming either α-tocopherol or placebo, performed prior to blood
transfusions.
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