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Clinical Trial Summary

This research aims to determine if melatonin supplementation, through improvements in sleep quality, increases the ability to repair oxidative DNA damage and reduce lipid peroxidation levels among nightshift workers.


Clinical Trial Description

Administering a 3 mg melatonin supplement to nightshift workers prior to day sleep may significantly improve their oxidative DNA damage repair capacity and reduce the occurrence of lipid peroxidation [measured as increased excretion of urinary 8-hydroxydeoxyguanosine (8-OH-dG) and decreased excretion of urinary 8-isoprostane, respectively] through improvements in sleep quality (measured via actigraphy) and melatonin's direct antioxidative properties. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03945955
Study type Interventional
Source University of British Columbia
Contact Parveen Bhatti, PhD
Phone 604-675-8055
Email pbhatti@bccrc.ca
Status Not yet recruiting
Phase Phase 4
Start date July 2019
Completion date September 2020

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