Oxidative Stress Clinical Trial
Official title:
Study the Effect of Blood Transfusion on Oxidant-antioxidant Status in Term and Near-term Neonates
Verified date | August 2020 |
Source | Ain Shams University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Primary aim is to evaluate the effect of blood transfusion on oxidant-antioxidant status in premature neonates. Secondary aim is to assess the effect of the age of transfused red blood cells on the biological markers of oxidative stress.
Status | Completed |
Enrollment | 65 |
Est. completion date | February 26, 2020 |
Est. primary completion date | November 1, 2019 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 35 Weeks to 37 Weeks |
Eligibility |
Inclusion Criteria: - Premature neonates =36 weeks in need for blood transfusion. Exclusion Criteria: - Critically ill neonates.(perinatal asphaxia,on high setting mechanical ventilation,different types of shock eg ;septic shock and major congenital anomalies) - Extremely low birth weight neonates(<1000gm birth weight ) - Recipient of blood transfusion before enrollment in the study. - Neonates planned for exchange transfusion . |
Country | Name | City | State |
---|---|---|---|
Egypt | Rania Farrash | Cairo |
Lead Sponsor | Collaborator |
---|---|
Rania Ali El-Farrash |
Egypt,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | malondialdehyde | MDA | 2-3 hours posttransfusion | |
Primary | total antioxidant capacity | TAC | 2-3 hours posttransfusion | |
Primary | serum Copper | s.Cu | 2-3 hours posttransfusion | |
Primary | serum Zinc | s.Zn | 2-3 hours posttransfusion | |
Primary | serum magnesium | s.Mg | 2-3 hours posttransfusion | |
Primary | serum iron | s.Fe | 2-3 hours posttransfusion | |
Primary | serum Calcium | s.Ca | 2-3 hours posttransfusion |
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