Oxidative Stress Clinical Trial
Official title:
Effects of a Cocktail XXS-2A/Omega-3 on Insulin Sensitivity and Oxidative Stress During a 20-day Period of Physical Inactivity: a Controlled, Randomized Pilot Study on 20 Healthy Men
This experiment consists on a 20-day reduction in daily step in free-living active
individuals to induce physical inactivity. This will be used to test the efficacy of the
anti-oxidant cocktail we aim to test as a new countermeasure in 2016 during the 60-d bed rest
planed by ESA/CNES.
The objective of this study is to investigate whether the cocktail of natural antioxidants
XXS-2A comprising vitamin E and coupled with omega-3 helps to prevent and / or reduce the
glucose intolerance and improve oxidative defenses induced by 20 days of physical inactivity
through daily step reduction
Although physical inactivity is reported to affect glucose tolerance within days of
inactivity, we selected a period of 20 days for the effect of the cocktail to take place and
assess secondary molecular mechanisms. The effect of this short period of inactivity on
metabolism will moreover be boosted during the last 10 days by taking fructose, a sugar found
in abundance in fruits, honey and juices, which is known to quickly trigger metabolic
deregulation.
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